HIGH-SPEED DUAL ENERGY DIGITAL SUBTRACTION ANGIOGRAPHY

描述(由申请人提供)： 美国有2000多个导尿室，每年进行100多万次冠状动脉插管手术和同等数量的非冠状动脉插管手术。科学研究实验室(SRL)建议开发一种改进的数字成像技术，用于可视化对比填充结构，该技术可应用于目前使用对比成像的所有情况，具有许多优于现有技术的优点。这项名为双能数字减影血管造影术(DEDSA)的技术使用了一种专有的X射线源，该光源依靠新型阳极涂层和X射线过滤器来提高对比剂的敏感度，同时抑制组织和骨骼的特征。信号源技术也可以应用于双能量对比增强数字减影乳房X光成像(CEDSM)，这是最近才被证明的。SRL已经在校准的人形模体中以及在切除的动物器官中展示了碘造影剂的DEDSA成像。在这个项目中，我们将演示使用Gd造影剂的能力。Gd-DTPA等化合物在DEDSA成像中具有许多优于碘的优点，包括改善组织消除和降低患者剂量，目前被广泛用作MRI造影剂。该项目的目标是开发和演示一种能够用于实时减影成像的DEDSA X射线源原型。该光源是基于外来阳极材料的电子轰击，其中一种在第一阶段展示了高功率，其余的将在第二阶段开发。一旦开发出这种光源，它将被优化，并用于演示和完善使用碘和Gd造影剂的DEDSA成像。

DESCRIPTION (provided by applicant): There are over 2000 catheterization laboratories in the U.S. performing over 1 million coronary catheterizations and an equivalent number of non-coronary catheterization procedures per year. Science Research Laboratory (SRL) proposes to develop an improved digital imaging technique for visualizing contrast-filled structures that could be applied in all cases where contrast imaging is currently used with many advantages over current techniques. The technique, Dual-Energy Digital-Subtraction Angiography (DEDSA), uses a proprietary x-ray source that relies on novel anode coatings and x-ray filters to enhance the sensitivity to contrast agent while suppressing features due to tissue and bone. The source technology also can be applied to dual-energy contrast enhanced digital subtraction mammography (CEDSM), which has only recently been demonstrated. SRL has demonstrated DEDSA imaging of iodine contrast agent within calibrated anthropomorphic phantoms as well as within excised animal organs. In this program we will demonstrate the capability of using gadolinium contrast agents as well. Gadolinium compounds (such as Gd-DTPA) offer many advantages over iodine for DEDSA imaging, including improved tissue cancellation and lower patient dose, and are currently widely used as MRI contrast agents. The goal of this program is to develop and demonstrate a prototype DEDSA x-ray source capable of being used for real-time subtracted imaging. The source is based on electron bombardment of exotic anode materials, one of which was demonstrated at high power in Phase I, and the rest of which will be developed in Phase II. Once this source is developed it will be optimized and used to demonstrate and perfect DEDSA imaging using iodine and gadolinium contrast agents.