Plasmodium Genome Database

描述（由申请人提供）：疟原虫基因组数据库<http://PlasmoDB.org>建立于2000年，旨在加快疟疾研究界对基因组规模数据集的访问，从恶性疟原虫的参考基因组序列开始。PlasmoDB整合了来自恶性疟原虫基因组计划的已完成和未完成的序列、遗传和光学制图数据、测序中心提供的已完成序列的精心注释、使用多种算法的DNA和预测基因/蛋白质序列的自动分析、与GenBank/EMBL和其他数据库的比较、来自不同物种的未完成基因组序列和疟原虫est，以及来自SAGE和微阵列项目的表达数据。所有信息被整合到一个全面的关系数据库中，方便用户查询。在线数据库每天从100多个国家的用户那里获得多达13 000次的点击，并在世界各地分发了数千份以cd为基础的副本。PlasmoDB最初是由Burroughs Wellcome基金的种子基金支持的；该申请寻求资金来维护和扩展数据库，以造福整个研究界。数据库增强是一项正在进行的研究和开发项目，其结果是广泛适用于任何生物体的基因组规模数据集的工具。具体目标力求：

DESCRIPTION (provided by applicant): The Plasmodium Genome Database <http://PlasmoDB.org> was established in 2000, to expedite access of the malaria research community to genomic-scale datasets, beginning with the reference genome sequence for P. falciparum. PlasmoDB incorporates finished and unfinished sequence from the P. falciparum genome project, genetic & optical mapping data, curated annotation of finished sequences provided by the sequencing centers, automated analyses of DNA and predicted genes/protein sequences using multiple algorithms, comparisons with GenBank/EMBL and other databases, unfinished genomic sequences and Plasmodium ESTs from various species, and expression data from SAGE and microarray projects. All information is incorporated into a comprehensive relational database, facilitating user queries. The on-line database receives up to 13,000 hits per day, from users in more than 100 countries, and many thousands of CD-based copies have been distributed worldwide. PlasmoDB was initially supported through a seed grant from the Burroughs Wellcome Fund; this application seeks funding to maintain and extend the database, for the benefit of the research community at large. Database enhancement is an ongoing research and development project, resulting in tools that are broadly applicable to genomic-scale datasets for any organism. Specific aims seek to: 1. Enhance access to PlasmoDB as a community resource, including development of an improved web interface for relational queries. 2. Provide a mechanism for community input and response, including implementation of comment forms (for the web site, gene annotation, and other data types), tracking responses to comments, and posting comments and responses at PlasmoDB. 3. Expand the depth and scope of data available, including expression profiling and proteomics data, etc. 4. Provide comparative analyses of Plasmodium species, facilitating identification of genes and regulatory elements, genetic mapping, evolutionary studies, etc. The overall goal of this project is to develop and maintain a database that expedites biological discovery, including the identification of drug targets and vaccine antigens useful in the fight against malaria.