Novel Therapeutics for Pandemic and Epidemic Flu

描述（由申请人提供）：急需流感的广谱治疗药物来解决流感大流行问题，这是全球公共卫生的主要威胁。我们已经提出了旨在产生能够阻断所有流感病毒株感染的新型融合蛋白的研究。具体而言，融合蛋白由抑制所有流感病毒活化的蛋白酶抑制剂和有助于富集药物并延长药物在呼吸道上皮上滞留的锚定结构域组成。在拟进行的I期研究中，我们将制备这种蛋白酶抑制剂及其融合蛋白，比较它们的体外功能活性，并选择最佳构建体进行II期研究。

DESCRIPTION (provided by applicant): Broad-spectrum therapeutics for influenza are critically needed to address the problem of influenza pandemics, a major threat to the public health globally. We have proposed studies that aim at generating a novel class of fusion proteins capable of blocking infections by all strains of influenza viruses. Specifically, the fusion protein is composed of a protease inhibitor that inhibits activation of all influenza viruses and an anchoring domain that helps to enrich the drug and prolong the drug retention on the respiratory epithelium. In the proposed phase I study, we will generate this proteinase inhibitor and its fusion proteins, compare their functional activities in vitro and choose the best construct for phase II study.