3D Surface Image Guided Therapy for Breast Irradiation

描述（由申请人提供）： 该SBIR计划的主要目标是开发一种新型3D图像引导自适应治疗（3D IGAT）技术，以提高部分乳腺照射（PBI）治疗过程中的辐射输送精度。我们建议根据术前CT扫描和治疗期间采集的患者乳房3D表面轮廓之间的准确配准进行患者重新定位和误差校正。3D乳房表面模型将通过3D表面成像系统采集，该系统将根据SBIR项目进行设计和原型制作。我们将开发一个可变形的生物力学有限元乳腺模型，建立3D表面图像和CT扫描之间的相关性，以获得皮下肿瘤的位置。将开发计算方法，以估计患者几何形状变化的真实输送剂量，并在输送剂量与计划剂量显著不同时，借助有限元乳腺模型自适应调整治疗计划。

DESCRIPTION (provided by applicant): The primary objective of this SBIR program is to develop a novel 3D image guided adaptive therapy (3D IGAT) technique to improve the precision of radiation delivery during the course of Partial Breast Irradiation (PBI) treatment. We propose to perform patient repositioning and error correction based on accurate registration between the pre-operative CT scan and the 3D surface profiles of patient's breast acquired during the treatment. The 3D breast surface model will be acquired by a 3D surface imaging system to be designed and prototyped under this SBIR project. We will develop a deformable biomechanical finite-element breast model that establishes correlation between the 3D surface images and CT scans to derive the subsurface tumor location. Computational methods will be developed to estimate the true delivered dose given variations in patient geometry and to adaptively adjust he treatment plan when the delivered dose differs significantly from the planned dose with the aid of the finite element breast model.