Mechanisms underlying the generation of spontaneous contractions in human uterine muscle: Potential therapeutic target for dysfunctional labour

成功的分娩结局对母子的健康至关重要。宫缩过快或在分娩过程中失败时，会对母婴产生重大的短期和长期后果。我们最近对分娩中妇女的组织进行的研究表明，引发子宫收缩的新的可能机制。我们现在将测试这些想法，以期确定操纵宫缩的新治疗目标。

Successful labour outcome is critical for the health of mother and offspring. Contractions too soon, or when they fail during labour, have significant short and long term consequences for mother and baby. Our recent studies on tissue from women in labour suggested new possible mechanisms underlying the initiation of uterine contractions. We will now test these ideas with a view to identifying new therapeutic targets for manipulating labour contractions.