Core--Mechanisms and Measures

该核心的目的是将压力，情绪和认知可能导致高血压（HTN）和慢性心血管疾病（CVD）发展的因果机制研究添加到现有的行为医学（BM）随机对照试验（RCT）中。将评估认知适应理论（CA）的一组心理测量测量和评估全静负荷（AL）模型的一组生化和生理测量标准化以创建两个电池。之所以选择这两种理论及其相关措施，是因为它们都认为压力对健康和疾病结果的影响有一个共同的机制。这一论点的必然结果是，BM干预，而利用不同的治疗，所有 通过一个共同的途径减少压力和对健康的影响。或者，可能存在与每种类型的BM干预相关联的一种独特机制。这个核心将使我们能够测试这些关于BM RCT影响疾病的方式的假设。 拟议的机制电池最初将在三个目前资助的行为随机对照试验中进行干预前后评估，其中最初不包括共同的机制假设。我们选择了三个随机对照试验，测试压力，愤怒和动机访谈干预对血压的影响。此外，该标准化组合将提供给正在进行或计划进行的其他RCT。

The purpose of this core is to add the study of causal mechanisms by which stress, emotions, and cognitions can contribute to the development of hypertension (HTN) and chronic cardiovascular diseases (CVD) to already existing Behavioral Medicine (BM) randomized controlled trials (RCTs). A set of psychometric measures that assess Cognitive Adaptation theory (CA) and a set of biochemical and physiological measures that assess the AIIostatic Load (AL) model will be standardized to create two batteries. These two theories and their associated measures were selected because they both argue that there is a common mechanism by which the effects of stress impact upon health and disease outcome. The corollary of this argument is that BM interventions, while utilizing distinct treatments, all operate to reduce stress and impact upon health through one common pathway. Alternatively, there may be one unique mechanism associated with each type of BM intervention. This core will allow us to test these conjectures about the ways in which BM RCTs impacts disease. The proposed mechanisms battery will initially be assessed pre- and post-intervention in three currently funded behavioral RCTs in which common mechanism hypotheses were not originally included. We have chosen three RCTs that are testing how stress, anger, and motivational interviewing interventions impact upon blood pressure. Additionally, this standardized battery will be made available to other RCTs that are either ongoing or planned.