UPCI CANCER EDUCATION AND CAREER DEVELOPMENT PROGRAMS

我们建议在早期发现和预防癌症方面发展跨学科的博士后培养计划。我们提出的癌症教育和职业发展（CECD）计划的总体目标是增加有资格进行跨学科转化癌症研究的年轻科学家的数量。我们的ced项目还将提供初步的职业发展，以促进他们向独立调查员的过渡。我们已经组建了一个多学科的导师团队，为这个项目开展教学、实验室和基于人群的研究培训。它将由四个部分组成：1)四个学期的生物统计学、癌症生物学和生物标志物、流行病学和人类遗传学的课程教学，包括完成公共卫生硕士学位；2)专门用于严格的研究培训和早期癌症检测或预防项目的时间；3)准备K22 NCI过渡职业奖申请；还有职业发展。在癌症生物标志物和分子流行病学方面开设了一门专门课程，将在该应用的重点领域提供跨学科的指导。该项目将以匹兹堡大学癌症研究所（UPCI）为基地，培训集中在最近资助的UPCI早期检测研究网络生物标志物发展实验室（EDRN/BDL）。我们计划招募7名研究员，他们将在基础生物医学科学方面完成博士水平的培训。招募将在全国范围内进行，利用期刊和国家会议广告、网络资源以及与EDRN研究人员的互动，随后进行个人面试，以确定具有转化性癌症研究职业承诺的最强候选人。UPCI全面的临床和研究资源，以及UPCI EDRN/BDL活动所突出的资金充足的教师导师的支持，共同为这些急需的跨学科科学家的博士后培训和最初的职业发展提供了理想的环境，以改善癌症的早期发现和预防。

We propose to develop an interdisciplinary postdoctoral training program in early detection and prevention of cancer. The overall goal of our proposed Cancer Education and Career Development (CECD) program is to increase the number of young scientists who are qualified to conduct interdisciplinary translational cancer research. Our CECD program will also provide initial career development to facilitate their transition to independent investigators. We have assembled a multidisciplinary team of mentors to carry out didactic, laboratory, and population-based research training for this program. It will consist of four components: l) four semesters of program-specific didactic instruction in biostatistics, cancer biology and biomarkers, epidemiology, and human genetics, including completion of a MPH degree; 2) time devoted exclusively to rigorous research training and a project in early cancer detection or prevention; 3) preparation of a K22 NCI Transition Career Award application; and 4) career development. A specialized course has been developed in Cancer Biomarkers and Molecular Epidemiology which will provide interdisciplinary instruction in the focus area of this application. This program will be based in the University of Pittsburgh Cancer Institute (UPCI) with training concentrated within the recently funded NCI Early Detection Research Network Biomarkers Developmental Laboratory (EDRN/BDL) of the UPCI. We anticipate recruiting seven Fellows into the program who will have completed doctoral level training in a basic biomedical science. Recruitment will be undertaken on a national level utilizing journal and national meeting advertisements, web-based resources, and interactions with EDRN investigators, followed by personal interviews to identify the strongest candidates with career commitment to translational cancer research. The comprehensive clinical and research resources of the UPCI, the support of the well-funded faculty mentors highlighted by the activities of the UPCI EDRN/BDL, together provide an ideal environment for postdoctoral training and initial career development of these critically needed interdisciplinary scientists to improve cancer early detection and prevention.