Prenatal Ultrasound And Birth Defects

描述（由申请方提供）：本研究将评估妊娠13 - 28周期间进行的产前超声检查的灵敏度和特异性，以检测约38种不同的胎儿结构畸形。目前，关于社区环境中这些发现率的现有证据很少。因此，这些信息将立即用于医生和孕妇，帮助他们做出明智的选择：1）常规产前超声检查的有用性2）先天性异常阴性超声检查的准确性和3）先天性异常阳性超声检查的准确性。我们计划建立一个由76,000名妇女组成的多种族队列，这些妇女在1998年至2006年期间在休斯顿的德克萨斯大学医学院进行了产前超声检查。超声波检查的计算机记录将与出生证明和胎儿死亡证明联系起来。他们还将与德克萨斯州出生缺陷登记处的记录联系起来，这是一个活跃的、基于人口的登记处，由德克萨斯州卫生服务部管理。这项拟议的研究将包括估计1,450名患有结构畸形的婴儿。这将是产前超声检测先天性异常能力的最具统计学意义的研究之一。将计算38种不同类型畸形的敏感性和特异性估计值。

DESCRIPTION (provided by applicant): This study will assess the sensitivity and specificity of prenatal ultrasound performed between 13 and 28 weeks of gestation to detect approximately 38 different structural malformations of the fetus. Currently, there is little available evidence concerning these detection rates in the community setting. Thus, this information will be of immediate use to physicians and pregnant women, assisting them in making informed choices concerning; 1) the usefulness of routine prenatal ultrasound examinations 2) the accuracy of ultrasound examinations that are negative for congenital anomalies and 3) the accuracy of ultrasound examinations that are positive for congenital anomalies. We plan to create a multi-ethnic cohort of 76,000 women who had prenatal ultrasound exams at the University of Texas Medical School at Houston between 1998 and 2006. Computerized records of ultrasound examinations will be linked with birth certificates and fetal death certificates. They will also be linked with records of the Texas Birth Defects Registry, an active, population based registry, administered by the Texas Department of State Health Services. The proposed study will include an estimated 1,450 infants with structural malformations. This will be one of the most statistically powerful studies of the ability of prenatal ultrasound to detect congenital anomalies. Estimates of sensitivity and specificity will be calculated for each of 38 different categories of malformations.