Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model

少年派：马黛尔·阿特金斯 公共ID：MRATKINS 摘要：评估肿瘤引起的肌肉恶病质是否由肌球蛋白缺陷引起 果蝇肿瘤模型中重链的产生和定位 恶病质是一种毁灭性的癌症相关疾病，每年影响数百万人。 而且是无法治愈的。目前，恶病质的定义是患者迅速失去5%的 体重、肌肉无力和潜在的慢性病。恶病质是 被认为是癌症的晚期后果。在这里，我们提供了初步数据 由本科生使用果蝇癌症恶病质模型获得。 令人兴奋的是，我们已经确定了在体内肿瘤早期发生的刻板印象变化。 发展。在这项研究中，我们将区分这些表型的来源，评估 它们在恶病质进展中的作用，并调查河马信号 Path正在调节恶病质的早期或晚期事件。我们将利用我们在 染色和成像以及新的社区工具，允许组织特异性基因 操纵以达到我们的目标。这些作品，由代表不足的人指挥 本科生研究人员和硕士研究生将揭开未知的面纱 癌症引起恶病质的病因学。这些成果，以及未来的翻译工作， 是发展早期诊断的基础，从而允许干预以预防 患者的恶病质进展。通过这种支持的过程，PI将建立 一个独立的研究项目，将阐明恶病质的最早步骤 肌肉的变化，并为代表性不足的人提供关键的培训和支持 实习生。

PI: Mardelle Atkins Commons ID: MRATKINS Abstract: Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model Cachexia is a devastating cancer associated disease which affects millions each year and yet is untreatable. Currently cachexia is defined in patients by rapid loss of >5% of body weight with muscle weakness and an underlying chronic condition. Cachexia is considered a late stage consequence of cancer. Here, we present preliminary data acquired by undergraduate students using a Drosophila model of cancer cachexia. Excitingly, we have identified stereotyped changes which occur in vivo early in tumor development. In this study we will distinguish the origins of these phenotypes, assess their contribution to cachexia progression, and investigate if the Hippo signaling pathway is regulating early or late events in cachexia.We will leverage our expertise in staining and imaging as well as new community tools which allow tissue specific genetic manipulation to achieve our goals. These works, conducted by underrepresented undergraduate researchers and master’s students will shed light on the unknown etiology of cancer induced cachexia. Results of these, and future translational works, are the foundation to developing earlier diagnostics permitting interventions to prevent cachexic progression in patients. Through the course of this support the PI will establish an independent research program which will illuminate the earliest steps of cachexic changes in muscles and provide critical training and support to underrepresented trainees.