UNC Research Training Program in Respiratory Diseases and Critical Care

项目摘要/摘要 这项新的T32计划的建议名为“北卡罗来纳大学呼吸系统疾病研究和培训计划” 北卡罗来纳大学教堂山分校的“危重护理”为6名医学博士研究生提供支持， 肺部疾病研究培训的医学博士/博士或博士学位，强调联合培训计划 医学和儿科实习生。该计划提供基础、翻译和临床方面的多学科培训 在内科和儿科的肺科和重症监护科以及我们的 三个致力于了解肺部健康和疾病的研究中心。我们的计划提供了一个培训 来自7名临床(2名)和基础科学(5名)的48名培训员(38名导师、8名初级导师和2名共同导师) 医学院的院系。医学博士实习生将在3-5年进入他们的临床和研究培训， 旨在为他们提供在学术肺部医学领域担任领导职务所需的技能。博士学位。 实习生通常在博士后奖学金的第二年进入，他们将很好地融入社会。 进入他们项目的基本、翻译和临床方面。每个实习生都会有一个学术指导 一个委员会，包括来自不同学科的导师，他们将促进他们的科学发展和职业生涯 发展，包括赠款撰写和领导技能。每个受训者都将被欢迎进入神的文化，威尔 以研讨会为例，它将植根于这种文化。肺脏研究的每个领域都是多学科的。 自然，并强调对基础、翻译、临床和影响的更广泛的知识 实习生问题。研究领域包括囊性纤维化、原发性纤毛运动障碍、特发性支气管扩张症、 健康与疾病呼吸道上皮细胞分子生物学、白细胞动力学及临床研究 慢性阻塞性肺疾病，ARDS期间呼吸道炎症、炎症和先天免疫反应的控制 和病毒感染，临床试验，比较有效性研究，定性叙述数据的分析，以及 重症监护、呼吸道、肺泡、呼吸道的基础蛋白质组学和翻译蛋白质组学的大型队列研究 微生物组在健康和疾病中的作用，物理、化学和微生物环境对伤害的反应 药物，以及哮喘的临床和基础科学研究。多学科交叉的新项目 自然包括ARDS和重症监护研究，CF研究计划，以及燃烧诱导 军队中的支气管炎，每一种都需要广泛的专业知识之间的跨学科互动 来实现他们的目标。临床研究将与基础观察相结合，使用翻译 生理学、生化、分子和基因技术以及组学方法，并将提供培训 在最先进的组学和其他基础技术、生物信息学、数据库设计、使用和分析中，以及 统计解释。重点是儿童和成人肺部疾病的潜在机制。 以及开发新的治疗策略。我们的计划为学员提供了一个发展的机会 作为科学家，并成为国家社区内的独立调查人员和领导人。

Project Summary/Abstract This proposal for a new T32 Program titled “UNC Research Training Program in Respiratory Diseases and Critical Care” at The University of North Carolina-Chapel Hill supports 6 postdoctoral trainees with M.D., M.D./Ph.D. or Ph.D. degrees for research training in lung disease, emphasizing a joint training program for Medicine and Pediatric trainees. The Program provides multidisciplinary training in basic, translation and clinical research within the pulmonary and critical care divisions of the Departments of Medicine and Pediatrics and our three Research Centers devoted to understanding lung health and disease. Our Program offers a Training Faculty of 48 trainers (38 mentors, 8 junior mentors and 2 co-mentors) from 7 clinical (2) and basic science (5) departments in the School of Medicine. M.D. trainees will enter at years 3-5 in their clinical and research training, designed to provide them with skills required for a leadership career in academic pulmonary medicine. Ph.D. trainees will typically enter in the second year of their post-doctoral fellowship, and they will be well integrated into the basic, translational and clinical aspects of their project. Each trainee will have a scholarly oversight committee that includes mentors from varying disciplines who will facilitate their scientific growth and career development, including grant writing and leadership skills. Each trainee will be welcomed into a DEI culture, will take workshops, and will become embedded in this culture. Each area of lung research is multidisciplinary in nature and emphasizes a broader knowledge of the basic, translational, clinical and impact implications for each trainee's question. Areas of research include cystic fibrosis, primary ciliary dyskinesia, idiopathic bronchiectasis, cell and molecular biology of airway epithelia in health and disease, leukocyte kinetics and clinical research in COPD, control of airway inflammation, inflammatory and innate immune responses during ARDS and bacterial and viral infections, clinical trials, comparative effectiveness research, analyses of qualitative narrative data, and large cohort studies in critical care, basic and translational proteomics of airways and alveoli, the airway microbiome in health and disease, the responses to injury by physical, chemical, and microbial environmental agents, and clinical and basic science studies in asthma. Novel programs that exemplify the multi-disciplinary nature include ARDS and Critical Care Research, the CF Research Program, and Combustion-induced Bronchitis in the Military, each of which require cross-disciplinary interactions amongst a wide range of expertise to accomplish their goals. Clinical studies will be integrated with basic observations using translational physiologic, biochemical, molecular and genetic technologies, and -omics approaches and will provide training in state-of-the-art –omics and other basic technologies, bioinformatics, database design, use and analyses, and statistical interpretation. Emphasis is on mechanisms underlying lung diseases in pediatric and adult populations and development of novel therapeutic strategies. Our Program provides an opportunity for trainees to develop as scientists and become independent investigators and leaders within the national community.