Melanoma Mutation Profiling For Personalised Treatment

黑色素瘤是一种侵袭性皮肤癌，是导致皮肤癌相关死亡的主要原因。疾病传播很难发现，而且极难治愈。随着个体化治疗的发展，包括小分子抑制剂治疗转移性黑色素瘤，这种惨淡的临床结果正在改变。在这里，我们试图确定患者肿瘤和循环肿瘤细胞的突变谱，以进行先进的个性化治疗。

Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.