Achieving successful treatment outcomes among adolescents and pregnant/postpartum women living with HIV in Kenya

项目摘要 概述：这个K24职业中期研究者奖在以患者为导向的研究和指导建议， 扩大高素质候选人丽莎阿布吉博士的研究和指导活动，重点是 改善高负担、低资源环境中艾滋病毒感染者的艾滋病毒和健康成果。 候选人：Abuogi博士是一位接受过儿科学、全球卫生和艾滋病毒培训的医生兼科学家， 科罗拉多丹佛大学教授。她也是UCD中心的高级研究员， 儿童医院艾滋病毒预防项目全球健康和医疗主任。阿布吉博士 以患者为导向的研究，以解决艾滋病毒健康结果的差异，包括保持护理和病毒 在感染艾滋病毒的孕妇、青少年和儿童中，她有一个持续的记录 并表现出对新研究人员成功指导的奉献精神。 指导计划：Abuogi博士已证明致力于为多样化的团体提供非常成功的指导 的学员。她有能力从广泛的研究合作中招募多学科的学员 和网络，结构化的方法，以确保高质量的指导，并承诺建立下一个 致力于研究的一代调查人员，旨在解决知识差距和改善艾滋病毒 结果。 研究计划：Abuogi博士提出的研究活动涉及NIH艾滋病研究优先办公室 跨领域研究的研究议程，包括实施和行为科学，健康 差距、培训和能力建设。利用她正在进行的NIH资助的研究， 采取行为干预措施，改善孕妇/产后的艾滋病毒护理结果 和 对 1, 病毒 妇女和青少年 年轻的艾滋病毒感染者（AYA），Abuogi博士提出了创新的新的以患者为导向的研究重点 干预措施的可持续影响旨在改善对护理和病毒抑制的参与。在Aim中 博士阿布奥吉将研究短期同行导航对长期持续重新参与的影响， AYA在停止导航后抗逆转录病毒治疗中的抑制。在目标2中， o t 确定 行为干预对这些人群护理过渡的影响。最后，在目标3中，她将探讨 患者和LHW对干预措施如何支持治疗成功以及非预期 同行领导的干预措施的后果，为这些干预措施的迭代调整提供信息。 提出 循证 提供 新 本申请中描述的研究将扩大我们对可持续影响的理解， 采取干预措施，改善感染艾滋病毒的弱势群体的治疗结果， 为新学员提供研究机会。

Project Summary Overview: This K24 mid-career investigator award in patient-oriented research and mentorship proposes to expand the research and mentorship activities of a highly qualified candidate, Dr. Lisa Abuogi, focused on improving HIV and health outcomes for people living with HIV in high burden, low resource settings. Candidate: Dr. Abuogi is a physician-scientist trained in pediatrics, global health, and HIV and an Associate Professor at the University of Colorado Denver (UCD). She is also a Senior Investigator in the UCD Center for Global Health and Medical Director of the Children's Hospital HIV Prevention Program. Dr. Abuogi conducts patient-oriented research to address disparities in HIV health outcomes, including retention in care and viral suppression, among pregnant women, adolescents and children living with HIV. She has a sustained track record of extramural funding and demonstrated dedication to successful mentorship of new investigators. Mentoring Plan: Dr. Abuogi has a demonstrated commitment to highly successful mentorship of a diverse group of mentees. She has the ability to recruit multidisciplinary mentees from a wide range of research collaborations and networks, a structured approach to ensure high quality mentorship, and a commitment to build the next generation of investigators committed to research aimed addressing knowledge gaps and at improving HIV outcomes. Research Plan: Dr. Abuogi's proposed research activities address NIH's Office of AIDS Research Priority Research agenda in Cross Cutting research that includes implementation and behavioral sciences, health disparities, and training and capacity building. Leveraging her ongoing NIH-funded research evaluating behavioral interventions to improve HIV care outcomes for both pregnant/postpartum and on 1, viral women and adolescents young adults living with HIV (AYA), Dr. Abuogi proposes innovative new patient-oriented research focused the sustainable impact f interventions aimed a improving engagement in care and viral suppression. In Aim Dr. Abuogi will examine the effect of short-term peer navigation on long-term sustained re-engagement and suppression in AYA on antiretroviral treatment after navigation is discontinued. In Aim 2, o t determine the impact of behavioral interventions on care transitions in these populations. Finally, in Aim 3, she will explore the perceptions of patients and LHW on how the interventions support treatment success as well as unintended consequences of peer-led interventions to inform iterative adaptations of these interventions. proposed evidence-based provide The newly research described in this application will expand our understanding of the sustainable impact of interventions aimed at improving treatment outcomes for vulnerable populations with HIV and research opportunities for new mentees.