Electron Spin Resonance Microanalyzer

描述(申请人提供)：电子自旋共振光谱分析是一种广泛使用的检测自由基和顺磁中心的技术。有超过23,000篇发表的生物医学研究论文引用了这项技术，特别是自旋标记的使用以及活性氧物种和活性氮物种的测量。然而，电子自旋共振的应用也扩展到化学、生物化学、物理、辐射测年，以及在石化勘探和炼油、石油状况监测、食品杀菌等许多领域的商业应用。从历史上看，电子自旋共振谱仪一直是非常大、非常昂贵的实验室设备，因此许多潜在用户不容易获得。建议开发一种小型、廉价、高灵敏度的电子自旋共振光谱仪，使更多的用户能够使用这一强大的分析技术。 与公共健康相关：自由基是许多疾病过程中的一个重要因素。我们建议制作一种简单、低成本、便携的分析工具来测量自由基，特别是在临床和生物医学研究环境中。

DESCRIPTION (provided by applicant): Electron spin resonance spectrometry is a widely used technique for the detection of free radicals and paramagnetic centers. There are over 23,000 published biomedical research papers citing this technique, particularly the use of spin labeling and measurement of reactive oxygen species and reactive nitrogen species. However, applications of electron spin resonance also extend into chemistry, biochemistry, physics, radiation dating, and commercial applications in petrochemical exploration and refining, oil condition monitoring, food sterilization and many other areas. Historically, electron spin resonance spectrometers have been very large, very expensive pieces of lab equipment that are therefore not readily accessible to many potential users. What is proposed is the development of a miniature, inexpensive, high sensitivity electron spin resonance spectrometer instrument that will make this powerful analytical technique accessible to a much broader range of users. PUBLIC HEALTH RELEVANCE: Free radicals are an important contributor to many disease processes. We propose to make a simple, low cost, portable analysis tool for the measurement of free radicals, particularly in clinical and biomedical research settings.