Elasmobranch Fish Model of Neurodegenerative Disease

描述(由申请人提供)：海洋生物医学技术公司计划为临床前药物发现开发人类疾病的专有弹性贝类鱼类模型。我们已经证实，棘鱼与人类疾病相关，并有可能为用于分析神经发病机制的其他脊椎动物模型提供一种更容易获得、更具成本效益的替代方案。在我们的弹性肌腱模型中，MBT已经确定了伴随着人类阿尔茨海默病(AD)和帕金森病(PD)的常见生物标记物、形态变化和生化变化。这种弹性分支模型也符合目前关于1-甲基-4-苯基-1，2，3，6-四氢吡啶(MPTP)引起的多巴胺能神经元丢失的模型，如在人类帕金森病中看到的那样。与其他脊椎动物相比，MBT弹性支链动物模型对异物和环境诱导的致病机制具有更高的敏感性，这是因为自然发生的抗氧化防御能力降低。我们的第一个目标是建立一个黄貂鱼的繁育种群。这一品种的黄貂鱼很容易适应圈养繁殖，并且具有最短的妊娠期。此外，这种物种的大脑与身体的比例很大，使其成为研究环境诱导的神经退行性疾病的理想模型。这些黄貂鱼有许多系统和同源代谢途径到达高等脊椎动物，包括哺乳动物。这些动物可以在相对较小的空间内培养，成本最低，并且在没有转基因的情况下具有自然减弱的抗氧化防御机制，增加了这种模式的经济效益。我们的坚定承诺是为大型制药公司以及来自行业和学术背景的个人科学家提供高效且具有成本效益的治疗性药物筛选服务。项目叙事海洋生物医学技术公司(MBT)正在开发一种棘目鱼类模型，以直接研究环境毒物的影响及其在包括帕金森氏症和阿尔茨海默病在内的神经退行性疾病中的作用。MBT将建立一个水产养殖设施来繁殖黄貂鱼；这些动物和产生的细胞系将大大有助于确定治疗退行性大脑疾病的新药物靶点。我们坚定地致力于为制药公司以及工业界和学术界的科学家个人提供高效、经济实惠的治疗药物筛选服务。

DESCRIPTION (provided by applicant): Marine Biomedical Technologies plans to develop proprietary elasmobranch fish models of human disease for preclinical drug discovery. We have established that elasmobranch fish demonstrate relevance to human disease and the potential to provide a more accessible, cost effective alternative to other vertebrate models used for analyzing neuropathogenesis. MBT has identified common biomarkers, morphological alterations, and biochemical changes which accompany both Alzheimer's disease (AD) and Parkinson's disease (PD) in humans, in our elasmobranch models. This elasmobranch model also conforms to current models with regard to 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) induced loss of dopaminergic neurons as seen in human PD. The MBT elasmobranch model offers greater sensitivity to xenobiotic and environmentally induced pathogenesis due to the naturally occurring reduced antioxidant defense capacity as compared to other vertebrates. Our first goal is to establish a breeding population of the species Urolophus jamaicensis (yellow stingray). This species of stingray is readily acclimated to captive breeding, and has the shortest gestation period of elasmobranch fishes. In addition, this species has a large brain to body ratio making it an ideal model for the study of environmentally induced neurodegenerative disease. These stingrays have many systems and homologous metabolic pathways to higher vertebrates, including mammals. These animals can be cultured in relatively little space, at minimal cost, and have a naturally diminished antioxidant defense mechanism without genetic modification, adding to the economic benefits of this model. It is our strong commitment to offer efficient and cost effective therapeutic drug screening services to large pharmaceutical companies as well as individual scientists from both industry and academic settings.Project Narrative Marine Biomedical Technologies Inc. (MBT) is in development of an elasmobranch fish model to directly study the effects of environmental toxicants and their role in neurodegenerative disorders including Parkinson's and Alzheimer's disease. MBT will establish an aquaculture facility to breed stingrays; these animals and cell lines generated will significantly aid in identifying new drug targets for the treatment of degenerative brain disorders. It is our strong commitment to offer efficient and cost effective therapeutic drug screening services to pharmaceutical companies as well as individual scientists from both industry and academic settings.