Metabolic regulation of ribosome biogenesis.

哺乳动物细胞已经形成了一个复杂的信号网络，负责监测和响应生长因子水平的变化以及环境中营养、能量和氧气的可获得性。放松对这一网络的管制往往会导致细胞生长失控，并导致心脏肥大和癌症等疾病。这项提议旨在了解这个网络如何控制细胞生长，并确定由不受控制的生长驱动的疾病的潜在靶点。

Mammalian cells have developed a complex signalling network responsible for monitoring and responding to changes in the levels of growth factors and the availability of nutrients, energy and oxygen in their environment. Deregulation of this network often results in uncontrolled cell growth and diseases including cardiac hypertrophy and cancer. This proposal aims to understand how this network controls cell growth and identify potential targets for diseases driven by uncontrolled growth.