Core--Immune Function and Inflammation

描述（由申请人提供）：背景和意义：免疫功能和 炎症核心：联合主任：Charles B。Stephensen博士Mark Shigenaga，PhD A 1.哮喘和其他慢性疾病与少数民族青年的肥胖有关目前席卷美国的肥胖流行病正在影响青少年和成年人，在非洲裔美国人和西班牙裔青年中尤为明显（Popkin和Udry 1998; Dwyer，Stone等2000）。青少年体重指数（BMI）的这种前所未有的增加是一种不健康的趋势，因为高BMI会增加患慢性疾病的风险，包括哮喘，2型糖尿病和心血管疾病。最近在城市非裔美国人和西班牙裔儿童和青少年中进行的研究证实了肥胖与哮喘风险的相关性（Gennuso，Epstein et al. 1998;吕德，Melnik et al. 1998; von Mutius，Schwartz et al. 2001）。除此之外，由于在不合标准的住房中暴露于过敏原的增加，内城儿童可能面临哮喘负担增加（埃格莱斯顿，Rosenstreich et al. 1998）。2型糖尿病长期以来被认为是与肥胖相关的成人发病疾病，现在在青少年中被诊断出来，特别是非洲裔美国人和西班牙裔美国人（Bourgeois 2002）。不良的健康行为（例如，高饮食胆固醇、增加的身体脂肪）是心血管疾病的危险因素，在非裔美国人中也更普遍， 西班牙裔青少年比他们的欧洲裔美国人（Fardy，Azz.ollini等人，2000年）。

DESCRIPTION (provided by applicant): Background And Significance: Immune Function And Inflammation Core: Co- Directors: Charles B. Stephensen, PhD. Mark Shigenaga, PhD A 1. Asthma and other chronic diseases are linked to obesity in minority youth The epidemic of obesity that is currently sweeping the U.S. is affecting adolescents as well as adults, and is particularly evident in African American and Hispanic youth (Popkin and Udry 1998; Dwyer, Stone et al. 2000). This unprecedented increase in body mass index (BMI) in adolescents is an unhealthy trend since high BMIs increase the risk of developing chronic disease, including asthma, type 2 diabetes and cardiovascular disease. Recent studies in urban African American and Hispanic children and adolescents have documented this association of obesity with asthma risk (Gennuso, Epstein et al. 1998; Luder, Melnik et al. 1998; von Mutius, Schwartz et al. 2001). This association is in addition to the increased burden of asthma that inner city children may face as a result of increased exposure to allergens in substandard housing (Eggleston, Rosenstreich et al. 1998). Type 2 diabetes, long considered an adult-onset disease associated with obesity, is now being diagnosed in adolescents, particularly African Americans and Hispanics (Bourgeois 2002). Poor health behaviors (e.g., high dietary cholesterol, increased body fat) that are risk factors for cardiovascular disease are also more prevalent in African American and Hispanic adolescents than in their European American counterparts (Fardy, Azz.ollini et al. 2000).