3rd US/EU Conference on Repair of Endogenous Genome Damage

描述（由申请人提供）：此R13会议资助提案要求对第三届美国/欧盟会议的部分支持，标题为“内源性基因组损伤的修复”。本次会议系列的广泛目标是促进美国和欧盟国家的科学家讨论内源性DNA损伤（主要是氧化性）处理的最新进展，包括修复及其在癌症，其他病理生理学和衰老中的作用。我们会议的一个重要目标是探讨合作努力，特别是在两个大陆的年轻调查人员之间。2003年在弗吉尼亚州的一次会议上发起了这一系列活动，取得了巨大成功。随后决定，这一系列会议将继续在隔年举行，地点将在美国和欧盟国家之间切换。因此，第二次会议于2005年11月在西西里举行。由于不可避免的原因，计划于2007年举行的第三届美国/欧盟会议被推迟到2008年11月5日至9日，并将在德克萨斯州加尔维斯顿的穆迪花园会议中心举行。得克萨斯州最古老的医学院--得克萨斯州加尔维斯顿的得克萨斯大学医学分支将是这次会议的共同赞助者。为期4天的会议将有100多名与会者参加，其中包括45名特邀演讲者和会议主席，美国和欧盟的代表人数相等。特别强调邀请年轻的调查人员参加演讲和海报展示。一些海报将被选为简短的口头介绍。将特别努力让妇女和少数群体科学家作为发言者和其他与会者。 这次会议的重点与其他类似会议不同，因为它对内源性DNA损伤的关注相当狭窄。这些损伤主要通过碱基切除和单链断裂修复（BER/SSBR）途径修复。BER/SSBR的多个子通路已经发展到处理发散损伤。此外，修复受多个参数调节，包括组织和细胞类型、细胞周期、细胞分化、基因组中病变的位置和染色质结构。将讨论自2005年会议以来在这些领域取得的新发现和由于修复缺陷而发现的疾病。最近的研究表明存在BER相互作用组，其中修复蛋白以协调的方式相互作用。核和线粒体基因组修复中的依赖性变化也将包括在内。修复过程的全面表征应具有重要的翻译意义。最后，这次会议专门讨论了我们的理解，未来的方向和领导人的挑战的现状应该是有益的，在维修领域的初级研究人员。

DESCRIPTION (provided by applicant): This R13 Conference grant proposal requests partial support for the 3rd US/EU Conference titled, "Repair of Endogenous Genome Damage". The broad objective of this Conference series is to promote discussion among scientists from US and EU countries about the recent advancements in processing of endogenous DNA damage (mostly oxidative) including repair and their role in cancer, other pathophysiologies and aging. An important objective of our meeting is exploration of collaborative efforts particularly among young investigators in two continents. The series was initiated with a meeting in Virginia in 2003 with great success. It was decided then that this conference series will continue to be held in alternate years and the venue will switch between a location in US and an EU country. Thus the 2nd conference was held in Sicily in November, 2005. For unavoidable reasons, the 3rd US/EU conference planned for 2007 was pushed back to November 5-9, 2008, and will be held in Moody Gardens Conference Center, Galveston, TX. The University of Texas Medical Branch in Galveston, the oldest medical school in Texas, will be a co-sponsor of this conference. The 4-day meeting will be attended by a little more than 100 participants including 45 invited speakers and session chairs, with equal representation from the US and EU. Special emphasis is placed on inclusion of young investigators both among invited speakers and poster presenters. Some of the posters will be selected for short oral presentation. Particular efforts will be made to include women and minority group scientists as speakers and other participants. The focus of this meeting is distinct from that of other, similar meetings because of its rather narrow focus on endogenous DNA damages. These damages are repaired primarily via the base excision and single- strand break repair (BER/SSBR) pathway. Multiple subpathways of BER/SSBR have evolved to process diverge damages. Furthermore, repair is regulated by multiple parameters, including tissue and cell types, cell cycle, cell differentiation, location of lesions in the genome and chromatin structures. New discoveries made in these areas and diseases due to repair deficiency identified since the meeting in 2005 will be discussed. Recent studies have suggested the existence of the BER interactome where the repair proteins interact with one another in a coordinated fashion. Age-dependent changes in repair of nuclear and mitochondrial genomes will also be covered. Comprehensive characterization of the repair processes should have significant translational implications. Finally, this conference devoted to discussion of the current state of our understanding, future directions and challenges by the leaders should be beneficial to the junior investigators in the repair field.