Region VI Center for Biodefense and Emerging Infections: Core E Small Animal Core

与新墨西哥大学(新墨西哥州阿尔伯克基)和西南大学有关的小动物核心 生物医学研究基金会(德克萨斯州圣安东尼奥)将： A)协助制定和执行调查员指导的研究方案， 需要动物模型来测试治疗、疫苗、诊断或增加我们对 寄主与病原菌的相互作用； B)培训研究人员和其他人员进行生物防御和新发传染病研究 与动物模型相关的活动； C)发展和维护支持动物模型研究和培训的设施 西部地区生物防御和新发传染病研究卓越中心 (WRCE)，并向来自学术界的合格研究人员提供这些核心设施， 生物技术公司、制药业和其他适当实体； D)开发有助于测试和验证疫苗的转化研究能力的模型， 生物防御和新出现的传染病的诊断和治疗概念；以及 E)向第一线应急人员提供和提供设施和科学支持 国家生物防御或新发传染病突发事件。 在这方面，小动物核心的最高优先事项将是提供标准化感染 为WRCE及其相关调查人员以及其他国家RCE测试新的 治疗性干预。小动物核心设施将向调查人员和公司开放 在我们地区以外的地区以合同为基础。核心将为生物治疗开发新的模型和分析方法 四个拟议研究主题所需的WRCE所需的代理，包括 开发RNA病毒的治疗方法，开发诊断平台，开发 虫媒病毒疫苗和新出现的传染病疫苗以及疾病疫苗的开发 由细胞内细菌引起。

The Small Animal Core associated with the University of New Mexico (Albuquerque, NM) and Southwest Foundation for Biomedical Research (San Antonio, TX) will: a) assist in the development and implementation of programs of investigator-directed research that require animal models for testing therapeutics, vaccines, diagnostics or increase our understanding of the host-pathogen interactions; b) train researchers and other personnel for biodefense and emerging infectious diseases research activities related to animal models; c) develop and maintain facilities that support the animal model research and training within the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE), and make available these core facilities to qualified investigators from academia, biotechnology companies, the pharmaceutical industry, and other appropriate entities; d) develop models that will assist in translational research capacity for testing and validating vaccine, diagnostic and therapeutic concepts for biodefense and emerging infectious diseases; and e) provide and make available facilities and scientific support to first-line responders in the event of a national biodefense or emerging infectious disease emergency. Within this context, the highest priority of the Small Animal Core will be to provide standardized infection models for the WRCE and its associated investigators, as well as other national RCEs for testing new therapeutic interventions. Small Animal Core facilities will be available to investigators and companies outside of our region on a contractual basis. The core will develop new models and assays for the biothreat agents as needed for the WRCE that are required for the four proposed research themes, including the development of therapeutics for RNA viruses, development of diagnostic platforms, the development of vaccines for arboviral and emerging infectious diseases, and the development of vaccines for diseases caused by intracellular bacteria.