Microbial Informatics Resource Core

拟议项目的总体长期目标是建立一个计算环境， 支持抗菌和反恐怖主义研究和开发。拟议的环境 将允许快速识别和表征生物战剂， 有效的遏制策略。我们将开发计算工具、算法， 数据库，用于分析、可视化和注释针对特定需求的数据， 微生物学研究和反恐工作，我们将提供无缝的环境， 将这些工具与国家计算网格（NSF TeraGrid）集成。发达 工具将允许鉴定和表征毒力因子，预测病原体的主要 生理和代谢特性，并估计其分类地位。我们将 利用国家计算科学联盟未来科学工作空间倡议 提供协作工具，使来自多个机构的研究人员能够进行协作 针对特定病原体的连贯项目上无缝衔接。我们还致力于发展和 部署工具，使学生和科学界的其他成员能够 高效和有效地培训使用计算生物学技术， 反生物恐怖主义工作的需要，并将有助于克服国家工人短缺， 计算生物学

The overall long-term goal of the proposed project is to establish a computational environment to support antimicrobial and antibioterrorism research and development. The proposed environment will allow rapid identification and characterization of biological warfare agents and the development of efficient strategies for their containment. We will develop computational tools, algorithms, and databases for analysis, visualization, and annotation of the data targeted to the particular needs of microbiology research and the antibioterrorism effort, and we will provide environment for seamless integration of those tools with the national computational Grid (the NSF TeraGrid). The developed tools will allow identification and characterization of virulence factors, prediction of pathogens' major physiological and metabolic characteristics, and estimation of their taxonomic positions. We will leverage the National Computational Science Alliance Scientific Workspaces of the Future initiative to provide collaboration tools that will enable investigators from multiple institutions to collaborate seamlessly on coherent projects focused on particular pathogens. We also aim to develop and deploy tools that will enable students and other members of the scientific community to be efficiently and effectively trained in the use of computational biology techniques for the particular needs of the anti-bioterrorism effort, and will help overcome the national shortage of workers in computational biology