FUNCTIONAL BRAIN IMAGING IN NORMAL AGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究假设：1）在影响感觉和认知处理的老化大脑中发生动态神经元网络特性的变化，2）这些变化可以通过脑磁图（MEG）进行量化。一般来说，虽然感觉处理发生在大脑的专门单位，认知绑定过程，改变了时间依赖性的方式，由老化过程，将导致修改的感觉运动整合。 目的如下：1）成像和分析丘脑-皮层诱发脑活动的时间重置。 2)研究正常人和老年人的躯体感觉阈值与初级感觉皮层神经活动的特定模式之间是否存在相关性。 3)对视觉诱发的丘脑-皮层脑活动的时间重置进行成像和分析。 4)分析语言知觉加工及其随年龄增长的变化。 将招募165名个体（25-80岁，每5岁15人一组），并进行神经心理学测试和自发和感觉诱发的MEG测量，以检测与4个目标相关的刺激的重置和结合参数。MEG结果将覆盖在MRI/MRS图像上，以揭示正常衰老中感觉和认知下降的潜在神经生物学相关性。此外，度量和光谱参数将用于定义受试者之间的相似性评分以及个体评分。个体评分可与神经心理学评估相关。临床和认知评估将每隔2年重复一次。 患者招募将包括现有的患者人群，然后由NIA支持的纽约大学阿尔茨海默病中心进行。六处也将提供特征良好、健康、认知正常的受试者。 这是一个大胆的尝试，以表征老化对神经元网络生理学的影响，特别是因为它涉及在短时间内处理输入刺激。 MEG和MRI/MRS的使用允许有关空间处理和神经元功能的信息。 研究人员开发了一种普朗克量子方法来处理感觉。 该程序已经启动，招募工作仍在继续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study hypothesizes the following: 1) Changes in dynamic neuronal network properties occur in the aging brain that affect sensory and cognitive processing and 2) these changes can be quantified by Magnetoencephalography (MEG). In general, although sensory processing occurs in dedicated units of the brain, the cognitive binding process, altered in a time-dependent manner by the aging process, will result in modifications of sensory-motor integration. The aims are the following: 1) To image and analyze the temporal reset of the auditory-evoked thalamo-cortical brain activity. 2) To investigate whether correlations exist between psychophysical somatosensory thresholds and specific patterns of neural activity in the primary sensory cortex in normal and aging individuals. 3) To image and analyze the temporal reset of visual-evoked thalamo-cortical brain activity. 4) To analyze language perception processing and its changes during aging. 165 individuals (in groups of 15 per 5-year age categories from 25-80) will be recruited and subjected to neuropsychological testing and spontaneous and sensory-evoked MEG measurements to detect reset and binding parameters from stimuli relating to the 4 aims. MEG findings will be overlaid on MRI/MRS images to reveal underlying neurobiologic correlates of sensory and cognitive decline in normal aging. In addition, metric and spectral parameters will be used to define similarity scores between subjects, as well as individual scores. The individual scores can be correlated with neuropsychologic assessments. The clinical and cognitive assessments will be repeated at 2-year intervals. Patient recruitment will include an existing population of patients followed by the NIA-supported Alzheimer's Disease Center at NYU. The Dept. of Psychiatry will also provide well-characterized, healthy, cognitively normal subjects. This is a bold attempt to characterize the effects of aging on neuronal network physiology, particularly as it relates to processing input stimuli in short bursts of time. The use of MEG and MRI/MRS allows for information about spatial processing and neuronal function. A Planckian quantal approach to sensory processing was developed by the investigators. This protocol has been initiated and recruitment continues.