ALTERED CALCIUM HOMEOSTASIS IN NEONATES ASSOCIATED WITH GENTAMICIN DOSING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在我们机构，庆大霉素用于足月和近月新生儿的剂量从2000年4月的q12小时间隔改为q24小时间隔。在接下来的15个月中，我们发现低钙血症的发生率(3.5%)高于在给予庆大霉素q12h剂量改变前15个月内所有新生儿观察托儿所住院的婴儿的回顾中检测到的发生率(0.4%)。以前的研究已经证明，服用庆大霉素会增加尿钙排泄，但还没有记录血清钙水平的变化。我们认为庆大霉素的应用不仅可以改变尿钙，还可以改变血钙。我们计划测定三组婴儿的血和尿电解质：25例接受q12小时庆大霉素治疗的婴儿，25例接受q24小时庆大霉素治疗的婴儿，以及10名未接受庆大霉素治疗的对照组婴儿。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our institution, gentamicin dosing for term and near-term neonates changed in April 2000 from a q12h interval to a q24h interval. During the ensuing 15 months, we discovered a higher incidence (3.5%) of hypocalcemia compared to the incidence (0.4%) detected in a retrospective review of cases of all infants admitted to the Observation Nursery within the Newborn Nursery during the 15 months prior to the dosage change when gentamicin as given q12h. Previous studies have demonstrated increased urinary excretion of calcium with gentamicin administration, but have not documented alterations in serum calcium levels. We propose that administration of gentamicin alters not only urinary calcium but also serum calcium. We plan to measure serum and urine electrolytes in three groups of infants: 25 infants receiving q12h gentamicin, 25 infants receiving q24h gentamicin, and 10 control infants not receiving gentamicin.