INSULIN SENSITIVITY IN ADOLESCENT GIRLS AT HIGH RISK FOR POLYCYSTIC OVARY SYN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多囊卵巢综合征(PCOS)影响全球5%-10%的育龄妇女，导致慢性无排卵，加速2型糖尿病及其前驱疾病的发病。我们假设胰岛素的异常作用先于并促进了成年多囊卵巢综合征患者的生殖功能障碍。我们将对比有记录的多囊卵巢综合征家族中的女孩在整个青春期对胰岛素的敏感性的模式，并确定青春期胰岛素作用障碍是否预示着多囊卵巢综合征的最终表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women worldwide, resulting in chronic anovulation and an accelerated onset of type 2 diabetes and its precursors. We hypothesize that aberrant insulin action precedes and facilitates the reproductive dysfunction seen in adult PCOS. We will contrast the patterns of insulin sensitivities throughout puberty in girls from families with documented PCOS, with and without associated glucose intolerance, to determine whether pubertal disorders of insulin action predict eventual expression of PCOS.