INTRAUTERINE GROWTH RETARDATION AND FETAL ADAPTIVE PROGRAMMING PILOT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议对7-9岁的前宫内生长受限(IUGR)婴儿进行一项关于长期脑发育、神经内分泌功能和细胞因子的初步研究。其目的是(1)首先通过这项初步研究确定受慢性宫内应激和营养剥夺导致IUGR影响最大的大脑区域，以便我们随后在新生儿(IUGR)发育期间进行有针对性的前瞻性调查；(2)确定IUGR婴儿的生长模式(线性、体重和追赶速度)及其与大脑(记忆)、炎症性(IL-6和肿瘤坏死因子)生长(IGF)细胞因子和神经内分泌和代谢(瘦素/脂肪、胰岛素/血糖和皮质醇/应激)功能的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose a pilot study of long term brain development, neuroendocrine function and cytokines in former Itrauterine Growth Restricted (IUGR) infants who and are now 7-9 years of age. The aims are (1) first identify the regions of the brain most affected by chronic intrauterine stress and nutritional deprivation leading to IUGR through this pilot study so that we subsequently perform targeted prospective investigations in the newly born (IUGR) infant during development; and (2) define growth patterns in IUGR infants (linear, weight, and velocity of catch-up) and their association with brain (memory), inflammatory (IL-6 and TNF) growth (IGF) cytokines, and neuroendocrine and metabolic (leptin/fat, insulin/glucose, and cortisol/stress) function later in life.