THE VENTILATORY RESPONSE TO OCCLUSION-INDUCED AROUSAL IN HEALTHY MEN AND WOMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的具体目的是：1）确定阻塞诱导的觉醒是否会导致高气道阻力人群（打鼾者）的呼吸不稳定，以及与觉醒后呼吸不稳定相关的因素; 2）确定打鼾者对阻塞诱导的觉醒的解释性反应是否大于非打鼾者;（3）确定健康男性和女性对阻塞引起的唤醒的解释性反应是否不同。 研究人员假设：a）阻塞引起的觉醒将在觉醒前气道阻力高的个体（打鼾者）中诱导恢复睡眠时的呼吸不稳定; B）打鼾者对阻塞引起的觉醒的解释性反应将高于非打鼾者;以及c）健康男性对阻塞引起的觉醒的解释性反应将高于女性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this study are to 1) determine whether occlusion induced arousal can induce breathing instability in people with high airways resistance (snorers) and what factors are related to breathing instability post arousal; 2) To determine whether the ventilatory response to occlusion-induced arousal is larger in snorers than non-snorers; and 3) to determine whether the ventilatory response to occlusion induced arousal is different between healthy men and women. The researchers hypothesize that a) occlusion-induced arousal will induce breathing instability on return to sleep in individuals who have high airways resistance prior to arousal (snorers); b) the ventilatory response to occlusion-induced arousal will be higher in snorers than in non-snorers; and c) the ventilatory response to occlusion-induced arousal will be higher in healthy men than in women.