VASCULAR FUNCTIONAL ABNORMALITIES AND DIABETIC FOOT ULCERATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项队列研究，对象为150名足部溃疡高危糖尿病患者、25名无足溃疡风险的糖尿病患者和25名健康对照受试者。这项研究的主要目的是确定可以预测足部溃疡的毛细血管和微动脉(微循环)和大动脉(大循环)的血管功能测量。更具体地说，将招募150名有足部溃疡风险的糖尿病患者，并对其进行长达三年的跟踪调查。一组25名非神经性疾病患者和一名25名健康受试者也将接受随访，作为对照。所有患者将在首次就诊18个月后重新检查。血管反应性是指血管扩张和增加血流量的能力，将通过在参与者身上使用非侵入性技术来测量。指示血管功能的生化因素也将被测量。最后，将进行前臂皮肤活检，以努力评估与血管功能损害有关的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cohort study of 150 diabetic patients at high risk of foot ulceration, 25 diabetic patients not at risk and 25 healthy control subjects. The main purpose of the study is to identify measurement of vascular function, of both the capillaries and arterioles (microcirculation) and large arteries (macrocirculation) that can predict foot ulceration. More specifically, 150 diabetic patients at risk of developing foot ulceration will be recruited and followed for a period up to three years. One group of 25 non-neuropathic patients and one of 25 healthy subjects will also be followed up to serve as controls. All patients will be re-examined 18 months after their initial visit. The vascular reactivity, which indicates the ability of the vessel to dilate and increase the blood flow, will be measured by employing non-invasive techniques in the participants. Biochemical factors that are indicative of vascular function will also be measured. Finally, forearm skin biopsies will be performed in an effort to evaluate the factors that are involved in the impairment of the vascular function.