VISCERAL ADIPOSITY AND CVD RISK IN WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肥胖已被公认为是II型糖尿病和心血管疾病的危险因素。随着肥胖问题在美国的流行程度和严重性的增加，以及发病年龄的下降，人们对肥胖的担忧也在增加。然而，以体重指数衡量的肥胖的影响似乎因种族而异。与白人相比，体重指数每增加一个单位，黑人的血压和甘油三酯的增幅就会更小，高密度脂蛋白的降幅也会更小。对这一现象的解释仍不清楚。 我们建议对肥胖与心血管风险关系中的种族差异与脂肪分布的差异进行评估。我们将通过对年轻成年黑人和白人女性的队列研究来做到这一点，这些女性之前作为NHLBI生长和健康研究的一部分进行了跟踪。在这项研究中，全身脂肪将通过双能X射线吸收法(DEXA)进行测定，腹内(或内脏)脂肪将通过磁共振成像(MRI)进行测量。我们还将利用在儿童和青少年时期收集的关于青春期成熟和饮食的信息来评估潜力

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has been well established as a risk factor for type II diabetes mellitus and cardiovascular disease. Concern about obesity has increased as the prevalence and severity of this problem in the United States has increased and the age at onset has decreased. However, the impact of obesity measured by body mass index appears to differ by race. For each unit increase in body mass index, blacks have less of an increase in blood pressure and triglycerides and less of a decrease in HDL cholesterol compared to whites. The explanation for this phenomenon remains unclear. We propose to evaluate the concept that these racial differences in the relationship of adiposity to cardiovascular risk are related to differences in the distribution of fat. We will do this through a cohort study of young adult black and white women who have been followed previously as part of the NHLBI Growth and Health Study. In this study, total body fat will be determined by dual energy x-ray absorptiometry (DEXA), and intra-abdominal (or visceral) fat will be measured by magnetic resonance imaging (MRI). We will also utilize information on pubertal maturation and diet collected on this cohort in childhood and adolescence to evaluate potential