THE ATLAS TRIAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管手术治疗压力性尿失禁(SUI)的满意率很高，但许多女性倾向于非手术治疗。两种常用的非手术治疗模式包括盆腔肌肉锻炼和阴道内可控阴道(后者指的是女性在阴道内佩戴的装置)。尽管这两种疗法普遍使用，但很少有信息比较它们的有效性。这项研究验证的假设包括：对于SUI，使用插管治疗比盆腔肌肉锻炼更有效(在治疗3个月后)，同时使用这两种治疗方法比单独使用任何一种治疗(在治疗3个月后)更有效。为了验证这些假设，女性将被随机分为阴道内可控阴道内保育器、盆腔肌肉锻炼组或联合组，为期12个月。回答将通过全球改进问卷和其他有效的问卷测量进行评估。这将为描述和比较这些SUI的非手术治疗的治疗成功率和受试者满意度提供重要信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although surgical treatment for stress urinary incontinence (SUI) has a high satisifaction rate, many women prefer non-surgical treatment. Two commonly-used modes of non-surgical treatment include pelvic muscle exercises and intravaginal continence pessaries (the latter refers to devices women wears in the vagina). Despite the common use of these two treatments, there is little information comparing their effectiveness. The hypotheses being tested with this study include that treatment with a pessary is more effective than pelvic muscle exercises for SUI (after 3 months of treatment) and that treatment with both of these therapies simultaneously is more effective than either treatment alone for SUI (after 3 months of treatment). To test these hypotheses, women will be randomized to either intravaginal continence pessary, pelvic muscle exercises, or combination for 12 months. Response will be assessed by Global Improvement questionnaire and other validated questionnaire measures. This will provide important information in describing and comparing treatment success and subject satisfaction with these non-surgical treatments for SUI.