SLEEP AND NOCTURNAL ENDOCRINE FUNCTION IN MDMA USERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 3，4-亚甲基二氧基甲基苯丙胺(MDMA，“摇头丸”)是一种越来越受欢迎的滥用精神活性药物，已被证明是一种有效的脑5-羟色胺(5-HT)神经毒素。越来越多的证据表明，在娱乐MDMA使用者中，MDMA也会对人类产生5-羟色胺损伤，使用MDMA可能会导致睡眠和神经内分泌功能的改变。由于5-羟色胺参与睡眠、昼夜节律和内分泌功能的调节，先前发现的睡眠和内分泌功能异常可能与MDMA引起的5-羟色胺损伤有关。这些研究旨在扩展以前关于MDMA使用者的睡眠和神经内分泌功能的研究，并探索MDMA使用者和匹配对照组的睡眠和夜间神经内分泌功能之间可能的相互关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is an increasingly popular psychoactive drug of abuse that has been shown to be a potent brain serotonin (5-HT) neurotoxin in animals. Growing evidence in recreational MDMA users indicates that MDMA can also produce 5-HT damage in humans, and that MDMA use may lead to alterations in sleep and neuroendocrine function. Since 5-HT is involved in the regulation of sleep, circadian patterns, and endocrine function, previously identified abnormalities in sleep and endocrine function may be related to MDMA-induced 5-HT injury. The proposed studies are intended to extend previous studies of sleep and neuroendocrine function in MDMA users, and explore possible interrelations between sleep and nocturnal neuroendocrine function in MDMA users and matched controls.