EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项多中心试点研究，旨在为最终的第三阶段试验制定方法。这项先导性研究的具体目标是：1)开发和验证提高NIPPV耐受性的策略，确定影响接受这种治疗方式的因素，并评估早期呼吸功能障碍的措施；2)开发和验证确定ALS能量平衡的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multicenter Pilot Study to develop methods for a definitive Phase III trial. The specific aims of this Pilot Study are 1) To develop and validate strategies to improve tolerability of NIPPV, to identify factors that influence acceptance of this treatment modality, and to evaluate measures of early respiratory dysfunction; and 2) To develop and validate methods to determine energy balance in ALS.