EARLY TREATMENT OF ALS W NUTRITION & NON-INVASIVE POSITIVE PRESSURE VENTILATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是调查传统与早期积极的营养和呼吸干预对生存率，功能结局和生活质量的影响。次要目标包括开发和验证改善NIPPV（无创正压通气）耐受性的策略;评估ALS早期呼吸功能障碍的测量结果和能量平衡的测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to investigate the effect of conventional versus early aggressive nutritional and respiratory intervention on survival, functional outcome and quality of life. Secondary objectives include the development and validation of strategies to improve tolerability of NIPPV (non-invasive positive pressure ventilation); evaluation of measurements of early respiratory dysfunction and determination of energy balance in ALS.