THE EFFECTIVENESS OF PERFECT TOUCH(R) IN IMPROVING CIRCULATION IN THE LOWER E

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 大约10%-20%的70岁以上的人患有外周动脉疾病(PAD)，在糖尿病患者中发病率较高，并随着年龄的增长而增加。在PAD中，腿部动脉粥样硬化性狭窄限制了流向四肢的血流，这与相当大的发病率、生活质量受损和心血管风险增加有关。间歇性气动按压(IPC)是一种很有前途的维持下肢循环的保守方法。许多研究表明，在使用IPC后，皮肤微循环以及动脉血流都得到了改善。然而，这些装置的生理作用机制和效率仍在研究中。 在这项研究中评估的Perfect Touch？在腔室数量、充气率和压力以及足部和腿部按摩能力方面与类似设备不同。这项建议将检验该装置在健康对照组和轻度至中度PAD(0.5；ABI&lt；0.9)患者(n=18)中的短期血管益处。血管参数将是踝关节/臂指数(ABI)、经皮氧分压(TcPO2)和皮肤灌注成像。足部局部皮肤氧合情况将在15分钟的IPC应用过程中进行评估，而其他措施将在治疗前后进行。此外，IPC施加在皮肤上的压力将在对照受试者中测量。这项研究将为量化完美触摸设备的IPC可能带来的好处提供初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 10-20% of individuals older than 70 years have peripheral arterial disease (PAD), with a higher prevalence among diabetic patients and with increasing age. In PAD, atherosclerotic narrowing of the leg arteries limits the blood flow to the extremities, which is associated with considerable morbidity, impaired quality of life, and increased cardiovascular risk. Intermittent pneumatic compression (IPC) is promising as a conservative means of maintaining the lower extremity circulation. A number of studies have shown improvement in skin microcirculation as well as in arterial blood flow after using IPC. However, the physiological mechanism of action and efficiency of the devices are still under investigation. The Perfect Touch¿, evaluated in this study, differs from similar devices in terms of the number of chambers, inflation rate and pressure as well as the capability of massaging both foot and leg. This proposal will examine the short-term vascular benefits of this device in healthy control and those with mild to moderate PAD (0.5<ABI<0.9) (n=18 each). The vascular parameters will be the ankle/brachial index (ABI), transcutanous oxygen tension (TcPO2) and skin perfusion imaging. Local skin oxygenation of the foot will be evaluated throughout the 15-minute IPC application, while other measures are taken before and after the session. Additionally, the pressure imposed by IPC on the skin will be measured in control subjects. This study will provide preliminary data for quantifying the benefits that could result from IPC with the Perfect Touch¿ device.