MACROMOLECULAR X-RAY CRYSTALLOGRAPHY CORE B

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 设计新疗法对抗新出现的细菌威胁的关键是确定潜在蛋白质靶点的三维结构。 高分子X射线晶体学提供了一个强大的实验工具，使我们能够获得必要的结构信息。 包含在结构数据中的丰富信息随后可用于确定蛋白质结构和功能之间的重要关系。 利用这些数据将直接导致制定新的机制来控制细菌的发病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Essential to the design of new therapies against emerging bacterial threats is the determination of the three-dimensional structure of potential protein targets. Macromolecular x-ray crystallography provides a powerful experimental tool that allows us to obtain that necessary structural information. The wealth of information contained within the structural data can subsequently be utilized in the determination of the important relationship between protein structure and function. Utilization of this data will lead directly to the formulation of new mechanisms to control bacterial pathogenesis.