IDENTIFICATION OF GENETIC, BIOCHEMICAL AND HORMONAL FACTORS CONTRIBUTING TO L

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 摘要： 克利夫兰诊所目前正在进行为期两年的孤立性房颤基因库研究，以产生有关房颤的遗传(遗传)基础的信息。房颤的病因仍不明确。遗传、生化或荷尔蒙因素可能导致孤立性心房颤动的发生或持续。这项研究的目的是建立一个血样基因库，以及收集房颤特有的表型数据，用于未来的研究。我们将收集500名已经或正在向克利夫兰诊所进行孤立性心房颤动住院或门诊评估的患者的血液样本和数据。这些数据包括从医疗记录、人口学、心电图学、超声心动图、实验室和心血管造影术数据(如果适用)获得的基线临床数据的收集。受试者将接受访问，以获得基本的人口统计数据，并将向受试者发放问卷，以收集当前的医疗数据。受试者的医疗记录将被审查，以收集病史并了解他/她在注册时的疾病状况。该登记处将从提交给克利夫兰诊所进行住院或门诊评估的受试者中额外招募500名正常对照。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract: The Lone Atrial Fibrillation Genebank study is currently being conducted by The Cleveland Clinic over a two year period to generate information about the hereditary (genetic) basis of atrial fibrillation. The etiology of atrial fibrillation remains poorly defined. Genetic, biochemical, or hormonal factors may contribute to the development or perpetuation of lone atrial fibrillation. The purpose of this study is to establish a genebank repository of blood samples along with collection of phenotypic data specific to atrial fibrillation to be used for future research. We will collect blood samples and data from 500 patients who have presented to or who are presenting to the Cleveland Clinic for inpatient or outpatient evaluation for lone atrial fibrillation. The data includes the collection of baseline clinical data obtained from the medical records, demographic, electrocardiographic, echocardiographic, laboratory and angiographic data (if applicable). Subjects will be interviewed for basic demographic data and a questionnaire will be given to the subjects to collect current medical data. The subjects' medical records will be reviewed to collect medical history and capture his/her disease status at the time of enrollment. The registry will enroll an additional 500 normal controls from subjects presenting to the Cleveland Clinic for inpatient or outpatient evaluation.