A Comprehensive Patient Based Outcome Measure for Heavy Menstral Bleeding

描述（由申请人提供）：克里斯汀·马特森博士是布朗大学/罗德岛普罗维登斯妇幼医院的妇产科助理教授。候选人的长期目标是发展独立的职业生涯，将临床研究与临床医学相结合。该候选人对大量月经出血的评估和治疗感兴趣，这是一个普遍的问题，有许多原因，包括结构异常，全身疾病（如出血性疾病）和排卵功能障碍。经期大出血对妇女的健康和生活质量有重大影响。必须对这种情况下的“患者体验”进行评估，并制定高质量的以患者为基础的结果衡量标准。拟议的职业发展计划包括一个多学科方案，旨在提供密切指导的面向患者的研究经验，并结合调查方法和复杂数据分析方面的结构化教学课程。候选人将与一个由7名成员组成的咨询委员会合作，为大量月经出血制定一个有效和可靠的基于患者的结果测量（“月经出血问卷”）。将探索和采用现有最先进的技术，开发“月经出血问卷”的电子格式。本研究的具体目的是：(1)确定妇科医生对评估月经大量出血妇女的仪器所要求的内容和特征；(2)探讨影响月经大量出血妇女生活质量的生理、心理和社会因素；(3)制定月经出血特异性问卷，评估出血量和“状况”特异性生活质量；(4)开发创新的电子方法，收集基于患者的月经大出血结局测量数据。

DESCRIPTION (provided by applicant): Dr. Kristen Matteson is Assistant Professor of Obstetrics and Gynecology at Brown University/Women and Infants Hospital of Providence, Rhode Island. The candidate's long-term goal is to develop an independent career combining clinical research with clinical medicine. The candidate is interested in the evaluation and treatment of heavy menstrual bleeding, a prevalent problem that has many causes including structural abnormalities, systemic diseases (such as bleeding disorders), and ovulatory dysfunction. Heavy menstrual bleeding has a major effect on women's health and the quality of women's lives. "Patient experience" with this condition must be evaluated and a high quality patient-based outcome measure must be developed. The proposed career development plan incorporates a multi-disciplinary program designed to provide a closely mentored patient-oriented research experience in association with a structured didactic curriculum in survey methodology and complex data analyses. In collaboration with a 7 member advisory committee, the candidate will develop a valid and reliable patient-based outcome measure ("The Menstrual Bleeding Questionnaire") for heavy menstrual bleeding. The most advanced available technology will be explored and employed for the development of the electronic format of "The Menstrual Bleeding Questionnaire". The specific aims of this study are (1)To determine the content and characteristics that gynecologists would require of an instrument for evaluation of women with heavy menstrual bleeding; (2)To explore the physical, psychological, and social factors that affect the quality of life of women with heavy menstrual bleeding; (3)To develop a menstrual bleeding-specific questionnaire that assesses amount of bleeding and "condition"-specific quality of life; (4)To develop innovative electronic methods of collecting data on patient-based outcome measures for heavy menstrual bleeding. RELEVANCE TO PUBLIC HEALTH: Heavy menstrual bleeding is a common problem that has a major impact on quality of life and health care utilization and costs. The quality of both clinical research and clinical care is adversely affected by the lack of a standardized comprehensive patient base outcome measure for women reporting heavy menstrual bleeding. This career development and research plan aims to develop a high quality patient - based outcome measure for heavy menstrual bleeding that can be used in clinical care and future research.