CHOLESTEROL REMOVING FROM DODAC VESICLES & LIPOSOMES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 全标题：从DODAC囊泡和脂质体中去除胆固醇，掺入蔗糖烷基酯，用β-环糊精。 我们的工作是对一类非离子表面活性剂进行物理化学研究，这些非离子表面活性剂由不同长度的烷基链组成，其中蔗糖部分为水基。现在我们着重研究囊泡或脂质体中浓度低于增溶临界点的浓度对几种囊泡性质的影响。 在这次访问中，我们与苏珊娜·桑切斯博士直接合作，试图澄清肉豆蔻衍生物在从双层中去除胆固醇的效果。实验将在DODAC囊泡和POPC脂质体中进行

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Cholesterol removing from DODAC vesicles and liposomes, doped with sucrose alkyl esters, with beta-cyclodextrin. Our work consists in the physical chemical study of a family nonionic surfactants, consisting in different length of alkylic chains with a sucrose moiety as hydrophyllic head. Now we emphasize the on effect of the presence of concentrations below the solubilization critical point in vesicles or liposomes, in order to study the effects on several vesicular properties. In this visit, in direct collaboration with Dr, Susana Sanchez, we are trying to clarify the effect of the presence of the myristil derivative in the removing of cholesterol from the bilayer. The experiments are going to be performed in DODAC vesicles and POPC liposomes