MRI OF MURINE CARDIAC FUNCTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用转基因小鼠研究心功能不全的遗传基础，需要准确描述心室功能。 每个心动周期大于16个时间帧的高空间分辨率MRI难以在短MRI成像会话中实现。 我们的假设是，快速采集，高时间分辨率SPECT有足够的空间分辨率，以准确地表征心脏功能的三维测量。这项初步研究的目的是将快速、高时间分辨率SPECT心室功能测量（舒张末期和收缩末期容积的LVEF和RVEF）与MRI获得的测量结果相关联。 如果快速SPECT可以准确地表征心脏功能，超声心动图初步筛选，SPECT的二次功能表征，和MRI的高空间分辨率测量的算法将提出充分表征转基因心力衰竭模型的心功能不全。 这些初步数据将用于赠款提案，以支持进一步发展这些技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Investigations of the genetic basis of cardiac dysfunction, using transgenic mice, require accurate characterization of ventricular function. High spatial resolution MRI of greater than 16 time frames per cardiac cycle is difficult to achieve in a short MRI imaging session. Our hypothesis is that rapid acquisition, high temporal resolution SPECT has sufficient spatial resolution to accurately characterize 3 dimensional measurements of cardiac function. The aim of this pilot study is to correlate rapid, high temporal resolution SPECT measurements of ventricular function (LVEF and RVEF from end-diastolic and end-systolic volumes) with those obtained by MRI. If rapid SPECT can accurately characterize cardiac function, an algorithm for echocardiography primary screening, SPECT for secondary functional characterization, and MRI for high spatial resolution measurements will be proposed to fully characterize cardiac dysfunction in transgenic models of heart failure. This preliminary data would be used in a grant proposal to support further development of these techniques.