ADMINISTRATIVE CORE

A.目的 贝勒医学院（Baylor College of Medicine）脆性X研究中心行政核心 指导和协调贝勒-埃默里脆性X射线中心的活动， 实现中心的总体目标，包括： 1.目的：改进脆性X综合征动物模型，利用动物模型了解脆性X综合征的发病机制， FMR 1的开发要求，并更好地定义体内试验 对治疗的评估。 2.鉴定和表征能够改变Fmr 1效应的小分子 模式生物中的突变。 3.确定人类中表达的、前突变大小的CGG重复序列的影响。 4.为贝勒大学和埃默里大学的研究人员提供进一步的合作互动 有着共同的兴趣和对脆性X综合征研究的承诺。 行政核心将继续通过资金管理实现这些目标 授予脆性X中心，并通过协调研究者和顾问的互动。 它还将提供有效的整合脆性X中心与父母的精神发育迟滞 发育障碍研究中心（MRDDRC）。

A. OBJECTIVE The objective of the Baylor College of Medicine (BCM) Fragile X Research Center Administrative Core is to direct and coordinate the activities of the Baylor-Emory Fragile X Center in a manner which will meet the overall objectives of the Center, including: 1. To improve animal models of Fragile X syndrome, to use animal models to understand the developmental requirements for FMR1 and to better define in vivo assays amenable to the assessment of treatments. 2. To identify and characterize small molecules capable of modifying effects of Fmr1 mutations in model organisms. 3. To define the effects of expressed, premutation-sized CGG repeats in humans. 4. To provide for further collaborative interactions among Baylor and Emory researchers with common interests and commitment to research in Fragile X syndrome. The Administrative Core will continue to meet these objectives through the administration of funds awarded to the Fragile X Center, and through the coordination of investigator and advisor interactions. It will also provide effective integration of the Fragile X Center with the parent BCM Mental Retardation Developmental Disabilities Research Center (MRDDRC).