SETTING THE STAGE FOR VERTEBRATES: THE ORIGIN OF CHORDATE SEGMENTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的长期目标是了解脊椎动物形态新颖性的进化和发展。本研究主要研究无脊椎动物文昌鱼(Branchiostoma Floridae)的发育遗传学。文昌鱼通常被认为是脊椎动物最接近的近亲：它的身体结构和基因组结构都与脊椎动物相似，但要简单得多。体节是一种新的形态，只在文昌鱼和脊椎动物中发现。在脊椎动物中，它们形成肋骨、脊椎动物、背部肌肉和真皮。目前的工作考察了发育基因表达模式和体节发育所需的基本基因网络的保守和变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of this research is to understand the evolution and development of vertebrate morphological novelties. This research focuses on the developmental genetics of the invertebrate chordate amphioxus (Branchiostoma floridae). Amphioxus is generally considered the closest living relative of the vertebrates: both its body plan and genomic organization are vertebrate-like, but much simpler. Somites are a novel morphology found only in amphioxus and vertebrates. In vertebrates, they give rise to ribs, vertebrate, back muscles and dermis. The current work examines the conservation and changes in developmental gene expression patterns and the basic gene network required for somite development.