DEVELOPMENT OF NOVEL HYDROQUINONE-BASED SERCA INHIBITORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议研究的总体目标是利用实验和计算技术相结合的方法，启动新型肌内质网钙ATPase(SERCA)抑制剂的开发。SERCA抑制剂不仅是研究该酶功能的有力工具，而且它们还被认为在癌症化疗中具有潜在的药用价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed research is to initiate the development of novel inhibitors of the enzyme sarco-endoplasmic reticulum calcium ATPase (SERCA) using a combination of experimental and computational techniques. Not only are SERCA inhibitors powerful tools for the study of the enzyme's function, but they are also believed to be of potential medicinal value for cancer chemotherapy.