Hormonal signals that regulate ovarian differentiation

卵泡发育是一个动态的过程，需要对多个细胞进行精细的调节。 在发育的每个阶段，卵巢中的类型对当地产生的和性腺外的因素做出反应。在……里面 这是我们项目的竞争性更新，我们将结合我们在核受体方面的各种专业知识， 小鼠模型、卵巢组织病理学、神经内分泌调节和信号转导三个方面的综合 以及高度互动的项目，以评估激活素、雌激素和卵泡刺激素信号传递到 调节卵泡发育。这些因素中的任何一个对正常信号的干扰都会导致 不孕不育或不育。我们将检验激活素在正常发育中起关键作用的假设。 在卵巢卵泡中，正常的卵泡发育需要通过雌激素受体α来传递信号 这不依赖于它与DNA雌激素反应元件的结合，而FSH通过 蛋白激酶A和随后的磷脂酰肌醇3-激酶途径同时脱离 抑制颗粒细胞分化和刺激分化的抑制途径。这项研究 项目和支持核心是：项目I，卵巢卵泡发育的激活素调节，Kelly博士 项目II，非经典雌激素受体在卵巢中的阿尔法作用，博士。 Larry Jameson，Jon Levine和Mary Hunzicker-Dunn；项目III，FSH刺激的信号调节 卵泡成熟，Mary Hunzicker-Dunn博士和Larry Jameson博士； 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 该方案项目中涉及的问题构成了生育率管制的实质。由我们的联合 我们将努力优化每个项目的进度，以更好地了解控制卵泡发育的情况。

Ovarian follicle development is a dynamic process that requires exquisite regulation of multiple cell types in the ovary in response to locally produced and extragonadal factors at each stage of development. In this competitive renewal of our Program Project we will combine our various expertise's in nuclear receptors, mouse models, ovarian histopathology, neuroendocrine regulation, and signaling into three comprehensive and highly interactive projects to evaluate the mechanisms by which activin, estrogen, and FSH signal to regulate ovarian follicular development. Interruption of the normal signaling by any of these factors results in infertility or subfertility. We will test the hypotheses that activin plays a critical role in normal development of the ovarian follicles, that normal follicular development requires signaling through estrogen receptor alpha that is not dependent on its binding to DNA estrogen response elements, and that FSH-directed signaling via protein kinase A and consequently the phosphatidylinositol 3-kinase pathway simultaneously disengages an inhibitory pathway that restrains granulosa cell differentiation and stimulates differentiation. The research projects and supporting cores are: Project I, Activin Regulation of Ovarian Follicle Development, Drs. Kelly Mayo and Teresa Woodruff; Project II, Nonclassical Estrogen Receptor Alpha Action in the Ovary, Drs. Larry Jameson, Jon Levine and Mary Hunzicker-Dunn; Project III, FSH-Stimulated Signals that Regulate Follicular Maturation, Drs. Mary Hunzicker-Dunn and Larry Jameson; Core A, Administrative Core, Dr. Mary Hunzicker-Dunn; Core B, Ovarian Procurement, Processing and Analysis Core, Dr. Teresa Woodruff. The issues addressed in the Program Project underlie the essence of the regulation of fertility. By our united efforts we will optimize progress on each project to better understand the control follicular development.