VALIDATION OF THE CLINICAL DEMENTIA RATING SCALE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 轻度认知障碍(MCI)已被认为是阿尔茨海默病(AD)进展的危险因素。目前，MCI通常通过临床检查和几种英文工具来识别，这些工具集成了可靠的辅助来源的信息。目前还没有这种经过验证的适应文化的工具可用于在波多黎各人口中筛查MCI。这项研究的目的是在文化上适应和验证临床痴呆症评分(CDR)量表，这是一种基于信息者的检查，用于评估波多黎各人口中患者的认知状况。对于文化适应，译者将在概念和语言对等、文化语境和俗语方面对阿根廷西班牙语版本的CDR进行修改。讲西班牙语的波多黎各人将评估修订后的CDR的清晰度、适当性和文书中使用的语言的文化相关性。为了验证该量表，CDR认证评估员将把该量表应用于60名个体，分为三组：正常受试者、无诊断的记忆主诉受试者和被诊断为痴呆症的受试者及其各自的告密者。心理学家将衡量受试者在几个认知领域的表现。CDR量表的有效性将通过测试的灵敏度和特异度以及阳性和阴性预测值来建立，该测试相对于记忆主诉患者和正常对照组AD患者的相对地位，通过z分数确定。在这项研究中，我们将MCI定义为在一个或多个认知域中客观记忆障碍至少比正常对照组低1.5标准差(SD)的受试者，以及在两个或更多认知域中客观记忆障碍大于或等于2.0标准差的AD患者。图形表示将通过接收器操作员特征(ROC)曲线来区分MCI受试者、痴呆和正常对照组。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mild cognitive impairment (MCI) has been recognized as a risk factor for progression to Alzheimer's disease (AD). Presently, MCI is usually identified by clinical examination and with several instruments in English that integrate information from a reliable collateral source. No such validated culturally adapted instrument is available for the screening of MCI in the Puerto Rican population. The aims of this study are to culturally adapt and validate the Clinical Dementia Rating (CDR) scale, an informant-based examination for the assessment of patient's cognitive status in the Puerto Rican population. For the cultural adaptation, a translator will revise the Argentinean Spanish version of the CDR in terms of conceptual and linguistic equivalence, cultural context, and colloquialisms. Spanish speaking Puerto Ricans will evaluate the revised CDR for clarity, appropriateness, and cultural relevance of the language used in the instrument. To validate the scale, a Certified CDR evaluator will apply the scale to 60 individuals divided into three groups: normal subjects, subjects with memory complaints without a diagnosis, and subjects diagnosed with dementia and their respective informants. A psychologist will measure the subject's performance in several cognitive domains. Validation of the CDR scale will be established by the sensitivity and specificity and the positive and negative predictive values of the test, with respect to the relative standing of patients with memory complaints and with AD from normal controls, determined through z-scores. In this study we define MCI as subjects with an objective memory impairment of at least 1.5 standard deviation (SD) below normal controls in one of more cognitive domain and AD patients with 2.0 SD or more in two or more cognitive domains.Graphic representation will be through receiver operator characteristic (ROC) curves for discrimination between MCI subjects, demented, and normal controls.