Pilot Project A

标题：试点项目A：胰岛素抵抗、脂联素和胰岛素抵抗的试点病例比较研究 波多黎各的子宫内膜癌 联合领导人：MDACC - Karen H. Lu，医学博士，妇科肿瘤学副教授 UPRCCC -吉列尔莫·托尔托莱罗-卢纳，医学博士，哲学博士、主任，癌症控制和 人口科学方案 摘要 子宫体癌是美国最常见的妇科恶性肿瘤， 2008年估计新增病例和7 470例癌症相关死亡。同样，在波多黎各， 是最常见的妇科恶性肿瘤，也是女性癌症的第三大原因，仅次于乳腺癌 和结肠直肠癌。2003年，共有321例子宫内膜癌新病例报告给 波多黎各癌症登记处，占妇女所有癌症的6%。最近的观察表明， 需要考虑新的途径，包括胰岛素和胰岛素样受体可能作用的证据。 生长因子系统我们将进行一项以医院为基础的病例比较试点研究，以评估 胰岛素抵抗和脂联素作为子宫内膜癌危险因素 在波多黎各妇女中。100名女性（21岁及以上）新诊断的组织学 确诊的原发性子宫内膜癌将在妇科肿瘤诊所选择， 波多黎各大学医学科学校区（UPR-MSC）的妇产科， 相比之下，在UPRMSC的两个妇产科诊所的与会者中选择了100名妇女。 参与者将接受一次面对面的采访，采访中收集了以下信息： 信息，吸烟和饮酒习惯，体重史，个人和家族病史，生殖和 月经史、避孕史和激素替代治疗史、不孕症史以及 体力活动。此外，妇女将接受人体测量和血液采集 用于测量胰岛素抵抗的样品。胰岛素抵抗（IR）将使用定量 胰岛素敏感性检查指数（QUICKI）。此外，与胰岛素相关的血清脂联素水平 将使用市售的定量夹心酶联免疫吸附试验（ELISA） 免疫测定法（ELISA）。将使用单变量和多变量非条件logistic回归模型， 评估子宫内膜癌与胰岛素抵抗和血清脂联素的关系。比值比 (OR)其95%置信区间将用于估计IR与 其他相关因素和子宫内膜癌。

Title: Pilot Project A: Pilot Case-Comparison Study of Insulin Resistance, Adiponectin and Endometrial Cancer in Puerto Rico CO-LEADERS: MDACC - Karen H. Lu, M.D., Associate Professor, Gynecologic Oncology UPRCCC - Guillermo Tortolero-Luna, M.D., Ph.D., Director, Cancer Control and Population Sciences Program ABSTRACT Cancer of the uterine corpus is the most common gynecologic malignancy in the United States, with 40,100 new cases and 7,470 cancer-related deaths estimated for 2008. Similarly, in Puerto Rico endometrial cancer is the most common gynecologic malignancy, and the third leading cause of cancer in women behind breast and colorectal cancer. In the year 2003, there were 321 new cases of endometrial cancer reported to the Puerto Rico Cancer Registry, accounting for 6% of all cancers in women. Recent observations suggest that new pathways need to be considered, including evidence for a possible role of insulin and the insulin-like growth factor system. We will conduct a case-comparison hospital-based pilot study to assess the role of insulin resistance and adiponectin, a biomarker of insulin resistance, as risk factors for endometrial cancer among Puerto Rican women. One hundred women (21 years and older) with a newly diagnosed, histplogically confirmed primary endometrial cancer will be selected at the Gynecologic Oncology clinic of the Department of Obstetrics and Gynecology at the University of Puerto Rico Medical Science Campus (UPR-MSC) and compared to 100 women selected among attendees to two Obstetrics and Gynecology clinics at the UPRMSC. Participants will undergo a face-to-face interview in which the following is collected: demographic information, smoking and drinking habits, weight history, personal and family medical history, reproductive and menstrual history, history of contraception and hormone replacement therapy, history of infertility, and levels of physical activity. In addition, women will undergo anthropometric measurements and collection of blood samples for measurements of insulin resistance. Insulin resistance (IR) will be measured using the quantitative insulin sensitivity check index (QUICKI). In addition, serum adiponectin levels, which correlate with insulin resistance, will be measured using a commercially available quantitative sandwich enzyme-linked immunoassay (ELISA). Univariate and multivariate unconditional logistic regression models will be used to assess the association of endometrial cancer with insulin resistance and serum adiponectin. The odds ratio (OR) and its 95% confidence intervals will be used to estimate the strength of the association between IR and other factors of interest and endometrial cancer.