GENETIC DETERMINANTS OF THE STRESS RESPONSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然下丘脑-垂体-肾上腺(HPA)轴的激活被认为是对应激反应的一种基本适应机制，但这种系统的长期激活对机体的健康构成了风险，因为高度分解代谢的糖皮质激素会拮抗胰岛素并增加血压，从而增加患糖尿病、高血压和动脉疾病的风险。我们的研究有以下具体目标：1)招募50名年龄在18-60岁之间的男性和女性参加GCRC门诊研究；2)测量皮质醇对Trier社会压力测试(TSST)的反应；以及3)研究心理应激(TSST)皮质醇反应的大小与代谢综合征指标(包括胰岛素敏感性、内脏脂肪和骨密度)的关系。了解应激反应和代谢综合征标志物之间的关系可能会导致糖尿病和心血管疾病预防的新策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the activation of the hypothalamic-pituitary-adrenal (HPA) axis can be regarded as a basic adaptive mechanism in response to stress, prolonged activation of this system presents a health risk to the organism as highly catabolic glucocorticoids antagonize insulin and increase blood pressure, thus increasing the risk for developing diabetes, hypertension, and arterial disease. Our study has the following specific aims: 1) to recruit 50 men and women ages 18-60 years into an outpatient GCRC study; 2) to measure the cortisol response to the Trier Social Stress Test (TSST); and 3) to examine the relationship between the magnitude of the cortisol responses to psychological stress (TSST) and markers of the metabolic syndrome, including insulin sensitivity, visceral fat and bone density. Understanding the relationship between the stress response and makers of the metabolic syndrome may lead to novel strategies of diabetes and cardiovascular disease prevention.