FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION: PROTOCOL 2 (FRAM 2)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 弗拉姆2是一项NIH申办的研究，有3个目标： 以了解艾滋病病毒感染者是否有血管异常，最终可能导致心脏病发作或中风 研究脂肪在他们体内的分布情况， 来了解他们的身体是如何处理脂肪和糖分的 联系参加弗拉姆1的HIV感染者，以确定他们是否有资格参加弗拉姆2的两次四家访视。 在这两次访问中，参与者将进行脂肪耐量测试，葡萄糖耐量测试，颈动脉超声，DEXA扫描和MRI。对于这5个程序中的每一个，参与者将获得40美元（总计200美元）。 此外，这些访视包括基线实验室抽签、体格检查（目视检查）、人体测量、自我问卷调查和访谈者管理的表格。 当这2次访视完成时，提取这些受试者2000年1月1日之前的医疗记录，包括药物、体重史、T细胞和病毒载量以及病史。 如果患者被视为失访或死亡或拒绝，将进行简要病历审查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FRAM 2 is an NIH-sponsored study that has 3 goals: to learn whether HIV-infected patients have abnormalities in their blood vessels that could eventually lead to heart attack or stroke to study how fat is distributed in their bodies, and to learn how their bodies handle fat and sugars. HIV-infected individuals who participated in FRAM 1 were contacted to determine if they were eligible and interested in the two four-house visits of FRAM 2. At these two visits, participants would have a Fat Tolerance Test, a Glucose Tolerance Test, a carotid ultrasound, a DEXA scan, and an MRI. For each of these 5 procedures, participants would receive $40 (up to a total of $200). Additionally, these visits include baseline lab draw, physical exam (visual inspection), anthropometry, self-administered questionnaires, and interviewer-administered forms. When these 2 visits had been completed, these participants' medical records are abstracted back to 01 January 2000 for their medications, weight history, T-cell and viral load, and medical history. If patients were deemed lost to follow-up or were deceased or refused, an abbreviated chart review will be conducted.