Hemostasis Clinical Research Network Protocols

描述(由申请人提供) 患有止血障碍的患者面临长期的问题和风险、艰难的治疗决定以及与治疗本身相关的风险。这些风险和并发症中的许多可以通过适当的干预策略来减少或预防。在治疗出血性疾病患者和需要输血的患者方面的进展要求：1)临床研究利用多机构合作网络，以获得足够数量的患者以获得有意义的答案；2)患者在参与此类试验时接受专门的临床护理。输血医学/止血(TMH)临床试验网络于2002年10月启动。杜兰大学健康科学中心是组成临床试验网络的17个核心站点之一。杜兰核心站点是利用路易斯安那出血和凝血障碍中心的基本基础设施和服务开发的，该中心为400多名止血障碍患者提供护理，并在出血障碍患者的积累和临床护理中发挥作用，同时参与临床试验。此外，杜兰骨髓移植单元在杜兰现场实施输血药物试验方面发挥了重要作用。杜兰现场的PI和Co-PI在网络最初5年的发展过程中发挥了不可或缺的作用，并在网络研究的发展和实施中发挥了不可或缺的作用。杜兰现场这一项目的目的是继续全面参与TMH网络活动，包括实施在最初赠款期间开发的试验以及在第二个5年授权期内在网络中实施的新协议的开发。

DESCRIPTION (provided by applicant) Patients with disorders of hemostasis are subject to long term problems and risks, difficult treatment decisions and risks associated with treatment itself. Many of these risks and complications can be lessened or prevented by appropriate intervention strategies. Advances in the management of patients with bleeding disorders and those requiring transfusions require: 1) that clinical studies utilize a multi-institutional cooperative network in order to accrue sufficient numbers of patients to achieve meaningful answers; and 2) that patients receive specialized clinical care while participating in such trials. The Transfusion Medicine/Hemostasis (TMH) Clinical Trials Network was initiated in October, 2002. Tulane University Health Sciences Center is one of the 17 core sites that comprise the clinical trials network. The Tulane core site was developed using the basic infrastructure and services of the Louisiana Center for Bleeding and Clotting Disorders which cares for over 400 patients with disorders of hemostasis, and serves a role in the accrual of patients with bleeding disorders as well as in their clinical care .while participating in clinical trials. In addition, the Tulane Bone Marrow Transplant Unit plays an important role in the implementation of transfusion medicine trials at the Tulane site. The PI and Co-Pi's from the Tulane site have played an integral role in the development of the network during it's initial 5 year period, and in the development and implementation of network studies. The purpose of this project at the Tulane site is to continue full participation in TMH network activities, both in the implementation of trials developed during the initial grant period as well as in the development of new protocols to be implemented in the network during the second 5 year award period.