A San Francisco Street Youth Cohort: At Risk and HIV+

描述（由申请人提供）：这是一个青少年医学试验单位在旧金山弗朗西斯科，加州大学旧金山弗朗西斯科（UCSF）和拉金街青年服务（Lancaster）之间的合作重新竞争的应用程序。旧金山弗朗西斯科针对RFA中概述的关键弱势群体：离家出走的无家可归者、滥用药物者和少数民族青年以及变性青年。我们的目标仍然是继续向易受感染和未感染艾滋病毒的高危青年伸出援手，并使他们安全地参与临床和行为研究。我们的目标是继续为今后进行艾滋病毒疫苗试验建立强大的基础设施。我们相信，我们为ATM的整体实力和广度做出了贡献，并满足了更新的期望。我们的网站是一个以社区为中心的ATU，而不是大学;将大学的专业知识与社区合作。我们的艾滋病毒阳性青年的主要临床人口在拉金街青年服务中心（Lennis）社区诊所接受医疗护理，我们现在已经在招募和转介到ATN研究的14个以上的其他社区网站。截至2005年3月1日，我们已经招募了77名受试者进入我们研究中心目前开放的临床和预防方案（021、022、023 B、024、025和0168），参与了多个方案开发团队（015，016 B，034，039和PACTG 1046），我们的一名工作人员是第一篇关于连接保护的论文的主要作者。UCSF青少年医学部是青少年医学研究和青少年临床服务的丰富资源。SF的ATU团队包括PI、Moscicki博士、我们的Connect to Protect（C2 P）团队成员Catherine Geanuracos、LCSW、Kevin Sniecinski和Colette Auerswald博士、研究协调员Bethany Certa、RN、BSN和J.B.莫拉汉ANP-C，和工作人员助理奈杰尔雷耶斯。在Lancaster，医学博士艾伦·塔格特，在拉金街青年服务艾滋病毒感染和未感染的青年超过九年。他和外展工作者石楠维斯布罗德有效地识别、筛选和招募了无家可归的年轻人参加试验。我们的诊所服务包括Leps，它有一个全面的，以青年为中心的，文化上适当的艾滋病毒护理模式，并在UCSF，积极的健康实践和儿科艾滋病计划。总之，我们的ATU网站是大学和社区之间的独特合作伙伴关系。在过去的5年里，我们坚定了我们的承诺，确保边缘化和弱势青少年参与研究的权利。“连接保护”项目扩大了我们与社区的参与，并将更多机构纳入我们的转介网络。我们认为，继续让旧金山弗朗西斯科湾区的高危青年参与临床和行为研究至关重要。

DESCRIPTION (provided by applicant): This is an application for the re-competition of the Adolescent Medicine Trials Unit in San Francisco, a collaboration between the University of California San Francisco (UCSF) and Larkin Street Youth services (LSYS). San Francisco targets the key vulnerable populations outlined in the RFA: runaway homeless, substance abusing and minority youth, as well as transgender youth. Our aims remain to continue outreach to vulnerable youth both HIV infected and uninfected at risk and to engage them safely in clinical and behavioral research. We aim to continue creating a strong infrastructure for performing HIV vaccine trials in the future. We believe we contributed to the overall strength and breadth of the ATM and meet the expectations for renewal. Our site is an ATU centered in the community rather than the university; bringing university expertise in partnership to the community. Our primary clinical population of HIV positive youth receives medical care at Larkin Street Youth Services' (LSYS) community clinic, and we now have engaged more than 14 other community sites in recruitment and referrals into ATN studies. As of March 1, 2005 we have recruited 77 subjects into currently open clinical and prevention protocols at our site (021,022, 023B,024, 025, and 0168), have participated in several protocol development teams (015, 016B, 034, 039 and PACTG 1046), and a member of our staff was lead author on the first paper to be completed about Connect to Protect. UCSF Division of Adolescent Medicine is a rich resource for adolescent medicine research and clinical services to youth. The ATU at SF team includes the PI, Dr. Moscicki, our Connect to Protect (C2P)team members Catherine Geanuracos, LCSW, Kevin Sniecinski, and Dr. Colette Auerswald, Study Coordinators Bethany Certa, RN, BSN and J.B. Molaghan ANP-C, and staff assistant Nigel Reyes. At LSYS, Alan Taggart, M.D., has served HIV infected and uninfected youth at Larkin Street Youth for over nine years. He and Heather Weisbrod, the outreach worker, have effectively identified, screened and recruited homeless youth into trials. Our clinic services include LSYS, which has a comprehensive, youth centered, culturally appropriate model of HIV care, and, at UCSF, the Positive Health Practices and Pediatrics AIDS Program. In summary, our ATU site is a unique partnership between the university and the community. During the last 5 years, we have solidified our commitment to ensure marginalized and vulnerable youths' right to participate in research. The Connect to Protect project has expanded our involvement with the community and has brought additional agencies into our referral network. We believe it is critical to continue to engage the high risk youth in the San Francisco Bay Area in clinical and behavioral research.