Molecular characteristation of the adiponectin receptors, AdipoR1 and AdipoR2: Identifying strategies to enhance adiponectin sensitivity and reduce cardiometabolic disease.
Molecular characteristation of the adiponectin receptors, AdipoR1 and AdipoR2: Identifying strategies to enhance adiponectin sensitivity and reduce cardiometabolic disease.
批准号:
nhmrc : 1074074
负责人:
金额:
$22.31万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2019-12-31
来源:
中文摘要
肥胖和2型糖尿病(T2D)增加了心血管疾病(CVD)的风险,心血管疾病是澳大利亚的主要死亡原因。需要新药来减少这些疾病的健康风险和经济负担。靶向激素受体以减少肥胖患者肝脏和骨骼肌中的脂肪储存可能会改善胰岛素敏感性,降低血糖水平,从而降低心血管疾病的风险。这项研究将研究这些受体是如何发挥作用的,以开发降低心血管疾病风险的新药。
英文摘要
Obesity and Type 2 diabetes (T2D) increase risk of cardiovascular disease (CVD), a leading cause of death in Australia. New drugs are required to reduce the health risks and financial burden of these diseases. Targeting hormone receptors to reduce fat storage in liver and skeletal muscle in obesity may improve insulin sensitivity and reduce blood sugar levels and therefore reduce CVD risk. This research will study how these receptors function in order to develop new drugs to reduce CVD risk.
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