Molecular determinants of susceptibility and progression in breast cancer

乳腺癌是异质性的，使管理成为一项挑战。包括“基底”型在内的高级别癌症具有侵袭性，通常见于年轻女性，并有远处扩散的倾向。它们也与BRCA1基因突变有关。我们将研究使一些女性易患乳腺癌的机制，允许癌症在大脑和肺部等远处生长的过程，以及DNA修复蛋白如何参与其中。这将有助于开发新的诊断工具和治疗方法。

Breast cancer is heterogeneous, making management a challenge. High-grade cancers including the ‘basal’ type are aggressive, often found in young women and have a propensity for distant spread. They are also associated with a BRCA1 gene mutation. We will study mechanisms that predispose some women to develop breast cancer, the process that allows cancers to grow at distant sites such as the brain and lungs, and how DNA repair proteins are implicated. This will allow development of new diagnostic tools and treatments.