Clinical Investigation Core

临床研究核心的主要目标是提高CFAR研究者的能力， 启动或扩大需要接触HIV-1感染者、临床研究人员和研究人员的艾滋病毒/艾滋病研究项目， 标本和/或数据，并指导初级和其他新的研究者在临床和社会， HIV相关行为研究。核心将为CFAR成员提供访问强大数据库的机会， 来自患者和其他临床研究参与者的人口统计学、临床和实验室数据 问题研究访问这些数据库可以访问以前收集的数据， 获得符合新研究资格标准的受试者。临床环境包括艾滋病 流行病学和人口健康系物质部研究计划 虐待、艾滋病中心传染病诊所、青少年艾滋病计划以及新的社会和 行为部分，包括预防干预研究中心。核心也将 在研究设计方面提供帮助，包括样本选择、把握度计算和 使用适当的分析方法。核心开发了一个集中的，用户友好的，高效的 提供跨临床护理和临床研究中心访问数据的网关，以促进临床 研究，并刺激临床和实验室研究人员之间的互动，以促进翻译 research.高级研究者指导初级和新研究者的指导会议将继续进行。 最后，核心将促进新的国际研究倡议。具体目标是：（1）促进 检索和共享目前在不同数据系统中可用的临床数据; 2）帮助识别 个人和/或他们的标本用于新的研究项目; 3）加快通知潜在的人类 新的和正在进行的研究项目的主题，并促进潜在的研究主题之间的互动 4）协助临床、社会科学和基础研究人员实现研究的严谨性 通过提供样本选择、研究和评估方面的专业知识， 设计、功效计算和适当的分析方法; 5）指导初级和新的研究人员， HIV相关研究的所有方面，包括研究设计、受试者入组、IRB要求， 与基础科学家合作，准备和重新提交赠款申请，并介绍和 6）提高研究人员进行研究的能力， 社会和行为要素，并将社会科学研究纳入现有或新的临床研究， 通过社会和行为科学方面最先进的咨询和支持服务; 7） 扩大国际艾滋病毒相关研究;以及8）教育临床医生了解艾滋病毒的最新发展 研究，以激发对调查重要的未解决的临床研究问题的兴趣。

The primary objectives of the Clinical Investigation Core are to facilitate the ability of CFAR investigators to initiate or expand HIV/AIDS research projects that require access to HIV-1 -infected individuals, clinical specimens and/or or data, and to mentor junior and other new investigators in both clinical and social and behavioral HIV-related research. The Core will provide CFAR members with access to robust databases with demographic, clinical, and laboratory data from among patients and others enrolled in clinical research studies. Queries to these databases can provide access to previously collected data and facilitate rapid access to subjects who meet eligibility criteria for new studies. The clinical settings include the AIDS Research Program of the Department of Epidemiology and Population Health, the Division of Substance Abuse, the AIDS Center Infectious Diseases Clinic, the Adolescent AIDS Program, and a new Social and Behavioral Component that includes the Prevention Intervention Research Center. The Core also will provide assistance in study design, including recommendations for sample selection, power calculations and the use of appropriate analytical methods. The Core has developed a centralized, user-friendly, efficient gateway to provide access to data across clinical care and clinical research sites, to facilitate clinical research, and to stimulate interactions among clinical and laboratory investigators to promote translational research. Mentoring sessions at which senior investigators mentor junior and new investigators will continue. Finally, the Core will facilitate new international research initiatives. The Specific Aims are: 1) To facilitate the retrieval and sharing of clinical data currently available in disparate data systems; 2) To assist in identifying individuals and/or their specimens for new research projects; 3) To expedite informing potential human subjects of new and ongoing research projects and facilitate interactions between potential research subjects and investigators; 4) To assist clinical, social science, and basic researchers in achieving rigor of study design and validity and generalizability of study results by providing expertise in sample selection, study design, power calculations, and appropriate analytical methods; 5) To mentor junior and new investigators in all aspects of HIV-related research, including study design, subject enrollment, IRB requirements, collaboration with basic scientists, preparation and resubmission of grant applications, and presentation and publication of research findings; 6) To increase the capacity of investigators to perform studies involving social and behavioral elements, and to build social science studies into existing or new clinical research, through state-of-the-art consultation and support services in the social and behavioral sciences; 7) To expand international HIV-related research; and 8) To educate clinicians about the latest developments in HIV research to stimulate interest in investigating important unresolved clinical research questions.