UCLA Center for AIDS Research (CFAR)

描述（由申请人提供）：本申请构成了加州/洛杉矶大学（UCLA）艾滋病研究中心（CFAR）赠款的更新。这笔赠款将资助UCLA艾滋病研究所内UCLA CFAR开展的活动和项目。加州大学洛杉矶分校CFAR成立于1988年，艾滋病研究所成立于1992年，以协调所有艾滋病研究，临床和教育活动在大学及其七个附属教学医院在一个中央管理。艾滋病研究所和CFAR的整体组织结构在2005年进行了重组，以更有效地管理在过去五年中增长了30%的教师，以及自我们提交上次更新申请以来增长了50%的CFAR适用补助金。此更新应用程序包括CFAR核心服务和活动，旨在通过基础，临床和行为科学提高对艾滋病毒/艾滋病的认识。加州大学洛杉矶分校CFAR的总体使命是在不同学科之间创造协同作用，从而在理解、预防和治疗艾滋病毒感染方面取得重大突破，特别强调高价值的跨学科合作。加州大学洛杉矶分校的CFAR由200多名研究人员组成，他们负责250多个研究项目，几乎涵盖了艾滋病毒/艾滋病生物学，临床研究和行为科学的所有方面。加州大学洛杉矶分校在艾滋病研究、教育和教学以及临床项目方面一直被列为顶尖机构。大都会洛杉矶是艾滋病流行的主要中心，也是全国文化最多样化的地区之一，我们的计划旨在接触这些多样化的社区。我们感到特别自豪的是，近年来，我们临床试验招募的患者中有50%是少数民族社区的成员。CFAR的作用是通过支持科学和行政核心设施，以及为非常有价值的合作研究项目提供种子补助金，促进大学内外的合作和建立联系。2008年1月至2008年12月第一年请求支助的行动计划概述如下：CFAR计划继续支助先前CFAR赠款资助的八个核心：行政核心、发展核心、病毒学/BSL 3组织培养核心、细胞计数核心、小鼠/人类嵌合体核心、基因和细胞治疗核心、粘液免疫学核心和生物统计学核心。根据不断变化的流行病学、需求评估、战略规划和修订的短期和长期目标，取消了两个核心，增加了一个临床研究促进核心和一个咨询核心。 核心A：行政核心（Zack，J.） 核心A描述（由申请人提供）：UCLA CFAR的行政核心将提供基础设施支持，为UCLA的所有艾滋病相关研究和项目增加价值。行政核心负责监督UCLA CFAR的所有运营和治理方面。加州大学洛杉矶分校CFAR和艾滋病研究所的联合管理为CFAR提供以下形式的支持：财政管理和赠款管理，设备和供应品采购，短期和长期规划，为CFAR研讨会、座谈会和智囊团提供行政支持（包括财务，编辑，图形设计和后勤支持），为科学家和外行制定教育计划，校园和社区为基础的外展活动，种子赠款和奖学金审查的行政支持，遵守所有UCLA，加州大学和NIH的要求，市场营销和筹款，回应信息和援助的请求（从NIH，从我们的同事和合作者，从新闻界和公众），并监督CFAR的所有日常活动。行政核心将通过方便、精简和反应迅速的行政业务，对所有CFAR方案进行高效、有效的管理。行政核心由CFAR的首席研究员杰罗姆扎克博士和CFAR的共同负责人陈博士共同监督，陈博士也是加州大学洛杉矶分校艾滋病研究所所长。本核心的具体目标是：目标1。项目开发：开发，实施和协调支持加州大学洛杉矶分校CFAR的广泛的研究活动，通过旨在最大限度地获得信息和援助，加强沟通和鼓励合作的灵活和响应的行政结构的计划。目标二。新研究者开发：促进所有加州大学洛杉矶分校艾滋病研究人员的工作，特别是初级，新的和少数民族的研究人员，通过具体的机制，如导师计划和IRB申请，人类受试者招募，数据分析和补助金的写作，减少时间，成本和努力的援助。目标3：工商管理：通过资助行政服务和全面协调研究活动、智囊团、种子赠款审查和艾滋病研究中心的其他活动，提供专门用于艾滋病研究的基础设施。

DESCRIPTION (provided by applicant): This application constitutes a renewal on the part of the University of California/Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its seven affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage a faculty that has grown by 30% in the last five years and CFAR-applicable grants that have risen by 50% since we submitted our last renewal application. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross-disciplinary collaborations. The UCLA CFAR consists of more than 200 faculty investigators who are responsible for more than 250 research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative research projects. The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short- and long-term goals, two cores were eliminated and a Clinical Research Facilitation Core and a Consultation Core are added. CORE A: Administrative Core (Zack, J.) CORE A DESCRIPTION (provided by applicant): The Administrative Core of the UCLA CFAR will provide infrastructure support that adds value to all AIDS-related research and programs at UCLA. The Administrative Core is responsible for overseeing all operational and governance aspects of the UCLA CFAR. The joint administration of the UCLA CFAR and the AIDS Institute provides the following forms of support for the CFAR: fiscal administration and grants management, procurement of equipment and supplies, short- and long-range planning, administrative support for CFAR symposia, colloquia, and think tanks (including financial, editorial, graphic-design, and logistical support), development of educational programs for scientists and laypersons, on-campus and community-based outreach activities, administrative support for seed grant and fellowship reviews, compliance with all UCLA, University of California and NIH requirements, marketing and fund-raising, respond to requests for information and assistance (from the NIH, from our colleagues and collaborators, from the press and public), and supervision of all of the day-to-day activities of the CFAR. The Administrative Core will provide efficient, effective management of all CFAR programs through an accessible, streamlined and responsive administrative operation. The Administrative Core is overseen jointly by the Principal Investigator of the CFAR, Dr. Jerome Zack, and the Co-Pi of the CFAR, Dr. In/in Chen, who is also the Director of the UCLA AIDS Institute. The specific aims of this Core are: Aim 1. Program Development: Develop, implement and coordinate programs that support the wide-ranging research activities of the UCLA CFAR through a flexible and responsive administrative structure designed to maximize access to information and assistance, to enhance communication and to encourage collaboration. Aim 2. New Investigator Development: Facilitate the work of all UCLA AIDS researchers, but particularly junior, new and minority investigators, through specific mechanisms, such as mentorship programs and assistance with IRB applications, human-subject recruitment, data analysis, and grant writing, that reduce time, costs, and effort. Aim 3. Business Affairs Administration: To provide an infrastructure dedicated to AIDS research through funding of administrative services and overall coordination of research activities, think tanks, seed grant reviews and other activities of the CFAR.